Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
UCP3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)    
Predicted Functional Partners:
GPAT4
Glycerol-3-phosphate acyltransferase 4.
      
 0.769
TSHB
Thyroid stimulating hormone subunit beta.
   
  
 0.701
PRDX3
Peroxiredoxin 3.
      
 0.694
PPARG
Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]
   
 0.675
TMEM26
Transmembrane protein 26.
      
 0.670
PCK1
Phosphoenolpyruvate carboxykinase 1.
   
  
 0.668
ENSAPLP00000020487
Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
      
 0.668
ACADM
Acyl-CoA dehydrogenase medium chain.
      
 0.667
TLR4
Toll like receptor 4.
      
 0.666
PPARGC1A
PPARG coactivator 1 alpha.
   
 0.654
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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