Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
WDR45BWD repeat domain 45B. (312 aa)    
Predicted Functional Partners:
ATG2B
Autophagy related 2B.
    
 0.992
WIPI1
WD repeat domain, phosphoinositide interacting 1.
   
0.952
WIPI2
WD repeat domain, phosphoinositide interacting 2.
   
0.950
ATG16L1
WD_REPEATS_REGION domain-containing protein.
     
 0.945
ATG7
Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]
    
 
 0.678
BECN1
Uncharacterized protein.
    
 
 0.654
WDR78
WD repeat domain 78.
      
 0.621
RAB40B
RAB40B, member RAS oncogene family.
 
    
 0.617
EPG5
Ectopic P-granules autophagy protein 5 homolog.
      
 0.589
WDR48
WD repeat domain 48.
      
 0.563
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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