Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PRKXUncharacterized protein. (345 aa)    
Predicted Functional Partners:
PRKAR1A
Protein kinase cAMP-dependent type I regulatory subunit alpha.
 
 
 0.990
PRKAR2A
Protein kinase cAMP-dependent type II regulatory subunit alpha.
 
 
 0.978
PRKAR1B
Protein kinase cAMP-dependent type I regulatory subunit beta.
 
 
 0.962
PRKAR2B
Protein kinase cAMP-dependent type II regulatory subunit beta.
 
 
 0.911
MAPKAPK3
MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.
   
 0.873
SMO
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 
 0.813
AKAP1
A-kinase anchoring protein 1.
    
 0.812
SUFU
SUFU negative regulator of hedgehog signaling.
    
 0.807
STK36
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
    
  0.787
PLN
Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
    
 0.771
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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