STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (620 aa)    
Predicted Functional Partners:
PTCH1
Patched 1.
    
 0.994
SHH
Sonic hedgehog signaling molecule.
    
 0.981
GLI1
GLI family zinc finger 1.
    
 0.972
GLI2
Uncharacterized protein.
    
 0.948
SUFU
SUFU negative regulator of hedgehog signaling.
     
 0.920
ENSAPLP00000021384
SSD domain-containing protein.
    
 0.914
PTCH2
SSD domain-containing protein.
    
 0.914
GLI3
Uncharacterized protein.
    
 0.877
KIF7
Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
 0.856
DHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
    
 0.855
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.