Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
NPC1NPC intracellular cholesterol transporter 1. (1285 aa)    
Predicted Functional Partners:
NPC2
NPC intracellular cholesterol transporter 2.
   
 0.993
SREBF2
Sterol regulatory element binding transcription factor 2.
    
 0.651
ENSAPLP00000023723
BHLH domain-containing protein.
    
 0.651
SREBF1
Uncharacterized protein.
    
 0.651
LAMP1
Lysosomal associated membrane protein 1.
    
 
 0.596
ANKRD29
Ankyrin repeat domain 29.
 
  
 
 0.577
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
  
 0.563
CD81
Tetraspanin.
    
 
 0.557
MBTPS1
Membrane bound transcription factor peptidase, site 1.
   
 
 0.545
INSIG1
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.
    
 0.527
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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