NGLY1 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NGLY1

N-glycanase 1. (650 aa)

Predicted Functional Partners:

KATNAL2

0.962

RAD23B

0.951

ENSAPLP00000026623

0.951

AMFR

0.927

PSMC1

0.919

DERL1

0.902

VCP

0.861

RPS27A

0.791

ENSAPLP00000023897

0.790

SPATA5L1

0.774

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMFR	DERL1	ENSAPLP00000011188	ENSAPLP00000025861	Autocrine motility factor receptor.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.998
AMFR	ENSAPLP00000023897	ENSAPLP00000011188	ENSAPLP00000023897	Autocrine motility factor receptor.	Uncharacterized protein.	0.926
AMFR	ENSAPLP00000026623	ENSAPLP00000011188	ENSAPLP00000026623	Autocrine motility factor receptor.	STI1 domain-containing protein.	0.705
AMFR	KATNAL2	ENSAPLP00000011188	ENSAPLP00000024028	Autocrine motility factor receptor.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.706
AMFR	NGLY1	ENSAPLP00000011188	ENSAPLP00000007491	Autocrine motility factor receptor.	N-glycanase 1.	0.927
AMFR	PSMC1	ENSAPLP00000011188	ENSAPLP00000016454	Autocrine motility factor receptor.	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family.	0.881
AMFR	RAD23B	ENSAPLP00000011188	ENSAPLP00000019081	Autocrine motility factor receptor.	RAD23 homolog B, nucleotide excision repair protein.	0.705
AMFR	RPS27A	ENSAPLP00000011188	ENSAPLP00000004982	Autocrine motility factor receptor.	Ubiquitin-like domain-containing protein.	0.847
AMFR	SPATA5L1	ENSAPLP00000011188	ENSAPLP00000003723	Autocrine motility factor receptor.	Spermatogenesis associated 5 like 1.	0.886
AMFR	VCP	ENSAPLP00000011188	ENSAPLP00000004138	Autocrine motility factor receptor.	Valosin containing protein; Belongs to the AAA ATPase family.	0.940
DERL1	AMFR	ENSAPLP00000025861	ENSAPLP00000011188	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Autocrine motility factor receptor.	0.998
DERL1	ENSAPLP00000023897	ENSAPLP00000025861	ENSAPLP00000023897	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Uncharacterized protein.	0.610
DERL1	ENSAPLP00000026623	ENSAPLP00000025861	ENSAPLP00000026623	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	STI1 domain-containing protein.	0.647
DERL1	KATNAL2	ENSAPLP00000025861	ENSAPLP00000024028	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.803
DERL1	NGLY1	ENSAPLP00000025861	ENSAPLP00000007491	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	N-glycanase 1.	0.902
DERL1	PSMC1	ENSAPLP00000025861	ENSAPLP00000016454	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family.	0.881
DERL1	RAD23B	ENSAPLP00000025861	ENSAPLP00000019081	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	RAD23 homolog B, nucleotide excision repair protein.	0.647
DERL1	RPS27A	ENSAPLP00000025861	ENSAPLP00000004982	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ubiquitin-like domain-containing protein.	0.604
DERL1	SPATA5L1	ENSAPLP00000025861	ENSAPLP00000003723	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Spermatogenesis associated 5 like 1.	0.897
DERL1	VCP	ENSAPLP00000025861	ENSAPLP00000004138	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Valosin containing protein; Belongs to the AAA ATPase family.	0.984