OTOG protein (Anas platyrhynchos) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

OTOG

Otogelin. (2847 aa)

Predicted Functional Partners:

FAU

0.799

BCHE

0.722

GP1BA

0.668

GLE1

0.579

NUP50

0.557

RAE1

0.538

U3IAV1_ANAPP

0.536

ENSAPLP00000031241

0.536

GP1BB

0.529

NUP35

0.527

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCHE	OTOG	ENSAPLP00000012397	ENSAPLP00000007751	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Otogelin.	0.722
ENSAPLP00000031241	GP1BB	ENSAPLP00000031241	ENSAPLP00000001728	F5/8 type C domain-containing protein.	Glycoprotein Ib platelet subunit beta.	0.454
ENSAPLP00000031241	OTOG	ENSAPLP00000031241	ENSAPLP00000007751	F5/8 type C domain-containing protein.	Otogelin.	0.536
ENSAPLP00000031241	U3IAV1_ANAPP	ENSAPLP00000031241	ENSAPLP00000004373	F5/8 type C domain-containing protein.	Plastocyanin-like domain-containing protein.	0.900
FAU	OTOG	ENSAPLP00000027823	ENSAPLP00000007751	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Otogelin.	0.799
GLE1	NUP35	ENSAPLP00000016260	ENSAPLP00000008879	GLE1 RNA export mediator.	Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family.	0.771
GLE1	NUP50	ENSAPLP00000016260	ENSAPLP00000007643	GLE1 RNA export mediator.	Nucleoporin 50.	0.690
GLE1	OTOG	ENSAPLP00000016260	ENSAPLP00000007751	GLE1 RNA export mediator.	Otogelin.	0.579
GLE1	RAE1	ENSAPLP00000016260	ENSAPLP00000002657	GLE1 RNA export mediator.	Ribonucleic acid export 1.	0.962
GP1BA	GP1BB	ENSAPLP00000025752	ENSAPLP00000001728	LRRCT domain-containing protein.	Glycoprotein Ib platelet subunit beta.	0.975
GP1BA	OTOG	ENSAPLP00000025752	ENSAPLP00000007751	LRRCT domain-containing protein.	Otogelin.	0.668
GP1BB	ENSAPLP00000031241	ENSAPLP00000001728	ENSAPLP00000031241	Glycoprotein Ib platelet subunit beta.	F5/8 type C domain-containing protein.	0.454
GP1BB	GP1BA	ENSAPLP00000001728	ENSAPLP00000025752	Glycoprotein Ib platelet subunit beta.	LRRCT domain-containing protein.	0.975
GP1BB	OTOG	ENSAPLP00000001728	ENSAPLP00000007751	Glycoprotein Ib platelet subunit beta.	Otogelin.	0.529
GP1BB	U3IAV1_ANAPP	ENSAPLP00000001728	ENSAPLP00000004373	Glycoprotein Ib platelet subunit beta.	Plastocyanin-like domain-containing protein.	0.454
NUP35	GLE1	ENSAPLP00000008879	ENSAPLP00000016260	Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family.	GLE1 RNA export mediator.	0.771
NUP35	NUP50	ENSAPLP00000008879	ENSAPLP00000007643	Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family.	Nucleoporin 50.	0.946
NUP35	OTOG	ENSAPLP00000008879	ENSAPLP00000007751	Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family.	Otogelin.	0.527
NUP35	RAE1	ENSAPLP00000008879	ENSAPLP00000002657	Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family.	Ribonucleic acid export 1.	0.948
NUP50	GLE1	ENSAPLP00000007643	ENSAPLP00000016260	Nucleoporin 50.	GLE1 RNA export mediator.	0.690

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.87

expected number of edges:

13

PPI enrichment p-value:

8.46e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016567

Protein ubiquitination

7 of 555

1.28

1.3

0.00013

GO:0006511

Ubiquitin-dependent protein catabolic process

6 of 429

1.32

1.27

0.00029

GO:0006508

Proteolysis

7 of 982

1.03

0.9

0.00069

GO:0019538

Protein metabolic process

9 of 3206

0.63

0.45

0.0081

GO:0043170

Macromolecule metabolic process

11 of 4794

0.54

0.44

0.00096

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031625

Ubiquitin protein ligase binding

4 of 174

1.54

0.93

0.0105

GO:0046935

1-phosphatidylinositol-3-kinase regulator activity

2 of 13

2.37

0.88

0.0241

GO:0030674

Protein-macromolecule adaptor activity

4 of 249

1.38

0.83

0.0141

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070449

Elongin complex

3 of 4

3.05

3.01

3.33e-06

GO:0000151

Ubiquitin ligase complex

6 of 246

1.57

2.06

3.28e-06

GO:0030891

VCB complex

2 of 2

3.18

1.88

0.00041

GO:1990234

Transferase complex

8 of 663

1.26

1.59

1.33e-06

GO:0031466

Cul5-RING ubiquitin ligase complex

2 of 6

2.7

1.55

0.0015

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33849568

(2021) The role of SOCS proteins in the development of virus- induced hepatocellular carcinoma.

4 of 27

2.35

2.42

2.37e-05

PMID:34803084

(2022) Viral deubiquitinases and innate antiviral immune response in livestock and poultry.

3 of 21

2.33

1.5

0.0016

PMID:29235573

(2017) Constitutively elevated levels of SOCS1 suppress innate responses in DF-1 immortalised chicken fibroblast cells.

3 of 40

2.05

1.15

0.0064

PMID:37762376

(2023) VHL L169P Variant Does Not Alter Cellular Hypoxia Tension in Clear Cell Renal Cell Carcinoma.

2 of 4

2.88

1.09

0.0109

PMID:37127643

(2023) The interactions between PML nuclear bodies and small and medium size DNA viruses.

2 of 8

2.58

0.87

0.0262

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1562

Protein neddylation, and 1-phosphatidylinositol-3-kinase regulator activity

9 of 19

2.85

10.36

5.25e-21

CL:1565

Mixed, incl. VCB complex, and Cullin, conserved site

8 of 10

3.08

10.19

6.14e-20

CL:1569

VCB complex, and SKP1 component, POZ domain

5 of 5

3.18

6.09

6.77e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla04120

Ubiquitin mediated proteolysis

4 of 98

1.79

1.9

7.07e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1234176

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

5 of 26

2.46

4.19

6.15e-09

MAP-1234174

Cellular response to hypoxia

5 of 32

2.37

4.01

1.05e-08

MAP-8951664

Neddylation

9 of 264

1.71

3.64

6.79e-12

MAP-983168

Antigen processing: Ubiquitination & Proteasome degradation

7 of 364

1.46

2.09

3.32e-07

MAP-983169

Class I MHC mediated antigen processing & presentation

7 of 419

1.4

1.91

6.97e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000151

Ubiquitin ligase complex

6 of 191

1.68

2.3

1.74e-06

GOCC:0070449

Elongin complex

2 of 3

3.0

1.68

0.00092

GOCC:0030891

VCB complex

2 of 2

3.18

1.68

0.00092

GOCC:0031466

Cul5-RING ubiquitin ligase complex

2 of 6

2.7

1.47

0.0021

GOCC:0031461

cullin-RING ubiquitin ligase complex

4 of 129

1.67

1.46

0.00064

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR024766

Zinc finger, RING-H2-type

2 of 3

3.0

0.9

0.0241

IPR016157

Cullin, conserved site

2 of 3

3.0

0.9

0.0241

IPR045093

Cullin

2 of 6

2.7

0.89

0.0241

IPR036317

Cullin homology domain superfamily

2 of 7

2.64

0.89

0.0241

IPR019559

Cullin protein, neddylation domain

2 of 6

2.7

0.89

0.0241

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00884

Cullin protein neddylation domain

2 of 6

2.7

1.15

0.0081

SM00182

Cullin

2 of 7

2.64

1.15

0.0081

SM00969

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.

2 of 27

2.05

0.76

0.0389

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