ARHGAP45 protein (Anas platyrhynchos) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

ARHGAP45

Rho GTPase activating protein 45. (1156 aa)

Predicted Functional Partners:

FAM174C

0.765

RBIS

0.715

LRRCC1

0.681

WDR18

0.680

TMEM259

0.676

POLR2E

0.635

PUM3

0.621

NCAPD3

0.616

VPS26B

0.605

DAZAP1

0.605

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP45	DAZAP1	ENSAPLP00000008055	ENSAPLP00000030793	Rho GTPase activating protein 45.	DAZ associated protein 1.	0.605
ARHGAP45	FAM174C	ENSAPLP00000008055	ENSAPLP00000005981	Rho GTPase activating protein 45.	Family with sequence similarity 174 member C.	0.765
ARHGAP45	LRRCC1	ENSAPLP00000008055	ENSAPLP00000015858	Rho GTPase activating protein 45.	Leucine rich repeat and coiled-coil centrosomal protein 1.	0.681
ARHGAP45	NCAPD3	ENSAPLP00000008055	ENSAPLP00000010669	Rho GTPase activating protein 45.	Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.	0.616
ARHGAP45	POLR2E	ENSAPLP00000008055	ENSAPLP00000030225	Rho GTPase activating protein 45.	RNA polymerase II subunit E.	0.635
ARHGAP45	PUM3	ENSAPLP00000008055	ENSAPLP00000002421	Rho GTPase activating protein 45.	Pumilio RNA binding family member 3.	0.621
ARHGAP45	RBIS	ENSAPLP00000008055	ENSAPLP00000024017	Rho GTPase activating protein 45.	Ribosomal biogenesis factor.	0.715
ARHGAP45	TMEM259	ENSAPLP00000008055	ENSAPLP00000006917	Rho GTPase activating protein 45.	Transmembrane protein 259.	0.676
ARHGAP45	VPS26B	ENSAPLP00000008055	ENSAPLP00000019482	Rho GTPase activating protein 45.	VPS26, retromer complex component B.	0.605
ARHGAP45	WDR18	ENSAPLP00000008055	ENSAPLP00000006601	Rho GTPase activating protein 45.	WD repeat domain 18.	0.680
DAZAP1	ARHGAP45	ENSAPLP00000030793	ENSAPLP00000008055	DAZ associated protein 1.	Rho GTPase activating protein 45.	0.605
DAZAP1	FAM174C	ENSAPLP00000030793	ENSAPLP00000005981	DAZ associated protein 1.	Family with sequence similarity 174 member C.	0.715
DAZAP1	LRRCC1	ENSAPLP00000030793	ENSAPLP00000015858	DAZ associated protein 1.	Leucine rich repeat and coiled-coil centrosomal protein 1.	0.605
DAZAP1	NCAPD3	ENSAPLP00000030793	ENSAPLP00000010669	DAZ associated protein 1.	Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.	0.531
DAZAP1	POLR2E	ENSAPLP00000030793	ENSAPLP00000030225	DAZ associated protein 1.	RNA polymerase II subunit E.	0.599
DAZAP1	RBIS	ENSAPLP00000030793	ENSAPLP00000024017	DAZ associated protein 1.	Ribosomal biogenesis factor.	0.678
DAZAP1	TMEM259	ENSAPLP00000030793	ENSAPLP00000006917	DAZ associated protein 1.	Transmembrane protein 259.	0.681
DAZAP1	VPS26B	ENSAPLP00000030793	ENSAPLP00000019482	DAZ associated protein 1.	VPS26, retromer complex component B.	0.529
DAZAP1	WDR18	ENSAPLP00000030793	ENSAPLP00000006601	DAZ associated protein 1.	WD repeat domain 18.	0.692
FAM174C	ARHGAP45	ENSAPLP00000005981	ENSAPLP00000008055	Family with sequence similarity 174 member C.	Rho GTPase activating protein 45.	0.765

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.911

expected number of edges:

11

PPI enrichment p-value:

2.24e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007035

Vacuolar acidification

4 of 11

2.23

2.14

7.25e-05

GO:0070072

Vacuolar proton-transporting V-type ATPase complex assembly

2 of 5

2.27

0.88

0.0243

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046961

Proton-transporting ATPase activity, rotational mechanism

4 of 15

2.1

2.0

0.00011

GO:0015075

Ion transmembrane transporter activity

5 of 184

1.1

0.79

0.0061

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016471

Vacuolar proton-transporting V-type ATPase complex

4 of 14

2.13

2.23

3.64e-05

GO:0000220

Vacuolar proton-transporting V-type ATPase, V0 domain

3 of 6

2.37

1.94

0.00022

GO:0000329

Fungal-type vacuole membrane

5 of 120

1.29

1.17

0.00057

GO:0098588

Bounding membrane of organelle

6 of 450

0.79

0.54

0.0104

GO:0031090

Organelle membrane

9 of 997

0.63

0.49

0.0018

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:26791325

(2016) Predicting chemotherapeutic drug combinations through gene network profiling.

5 of 27

1.94

2.06

5.26e-05

PMID:36422040

(2022) Subunit C of V-ATPase-VmaC Is Required for Hyphal Growth and Conidiation in A. fumigatus by Affecting Vacuolar Calcium Homeostasis and Cell Wall Integration.

4 of 15

2.1

1.75

0.00038

PMID:24708151

(2014) A functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system.

4 of 18

2.02

1.68

0.00047

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2344

Vacuolar proton-transporting V-type ATPase complex

4 of 13

2.16

2.29

2.95e-05

CL:7052

Mixed, incl. Vacuolar proton-transporting V-type ATPase complex assembly, and Exopolyphosphatase activity

4 of 19

1.99

2.08

5.45e-05

CL:7055

Mixed, incl. Glycine transport, and Cactus-binding C-terminus of cactin protein

3 of 6

2.37

2.0

0.00017

CL:2348

Insulin receptor recycling

3 of 8

2.24

1.91

0.00022

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

spo04145

Phagosome

4 of 33

1.75

1.85

7.82e-05

spo00190

Oxidative phosphorylation

4 of 65

1.46

1.34

0.00049

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

SPO-917977

Transferrin endocytosis and recycling

4 of 13

2.16

2.38

1.85e-05

SPO-77387

Insulin receptor recycling

4 of 13

2.16

2.38

1.85e-05

SPO-1222556

ROS and RNS production in phagocytes

4 of 14

2.13

2.37

1.85e-05

SPO-9639288

Amino acids regulate mTORC1

4 of 20

1.97

2.27

1.85e-05

SPO-168249

Innate Immune System

5 of 191

1.09

0.89

0.0017

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016471

Vacuolar proton-transporting V-type ATPase complex

4 of 14

2.13

2.26

3.15e-05

GOCC:0000220

Vacuolar proton-transporting V-type ATPase, V0 domain

3 of 6

2.37

2.04

0.00014

GOCC:0005774

Vacuolar membrane

5 of 133

1.24

1.12

0.00060

GOCC:0031090

Organelle membrane

9 of 616

0.83

0.77

7.33e-05

GOCC:0098588

Bounding membrane of organelle

6 of 313

0.95

0.77

0.0016

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0375

Hydrogen ion transport

4 of 33

1.75

1.68

0.00023

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