| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADH5 | NTHL1 | ENSAPLP00000014719 | ENSAPLP00000008072 | S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | 0.777 |
| APEX1 | ENSAPLP00000017030 | ENSAPLP00000018420 | ENSAPLP00000017030 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | 0.831 |
| APEX1 | FEN1 | ENSAPLP00000018420 | ENSAPLP00000001147 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.951 |
| APEX1 | MLH1 | ENSAPLP00000018420 | ENSAPLP00000025394 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | MutL homolog 1. | 0.491 |
| APEX1 | NEIL3 | ENSAPLP00000018420 | ENSAPLP00000013102 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Nei like DNA glycosylase 3. | 0.479 |
| APEX1 | NTHL1 | ENSAPLP00000018420 | ENSAPLP00000008072 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | 0.990 |
| APEX1 | OGG1 | ENSAPLP00000018420 | ENSAPLP00000030972 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | 8-oxoguanine DNA glycosylase. | 0.850 |
| ENSAPLP00000017030 | APEX1 | ENSAPLP00000017030 | ENSAPLP00000018420 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | 0.831 |
| ENSAPLP00000017030 | FEN1 | ENSAPLP00000017030 | ENSAPLP00000001147 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.572 |
| ENSAPLP00000017030 | MLH1 | ENSAPLP00000017030 | ENSAPLP00000025394 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | MutL homolog 1. | 0.555 |
| ENSAPLP00000017030 | NEIL2 | ENSAPLP00000017030 | ENSAPLP00000010859 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Nei like DNA glycosylase 2. | 0.611 |
| ENSAPLP00000017030 | NEIL3 | ENSAPLP00000017030 | ENSAPLP00000013102 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Nei like DNA glycosylase 3. | 0.671 |
| ENSAPLP00000017030 | NTHL1 | ENSAPLP00000017030 | ENSAPLP00000008072 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | 0.663 |
| ENSAPLP00000017030 | OGG1 | ENSAPLP00000017030 | ENSAPLP00000030972 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | 8-oxoguanine DNA glycosylase. | 0.604 |
| ENSAPLP00000017030 | SNRPB | ENSAPLP00000017030 | ENSAPLP00000011634 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | Small nuclear ribonucleoprotein-associated protein. | 0.814 |
| FEN1 | APEX1 | ENSAPLP00000001147 | ENSAPLP00000018420 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | 0.951 |
| FEN1 | ENSAPLP00000017030 | ENSAPLP00000001147 | ENSAPLP00000017030 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. | 0.572 |
| FEN1 | MLH1 | ENSAPLP00000001147 | ENSAPLP00000025394 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | MutL homolog 1. | 0.771 |
| FEN1 | NEIL2 | ENSAPLP00000001147 | ENSAPLP00000010859 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Nei like DNA glycosylase 2. | 0.555 |
| FEN1 | NEIL3 | ENSAPLP00000001147 | ENSAPLP00000013102 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Nei like DNA glycosylase 3. | 0.733 |