TRIO protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

TRIO

Trio Rho guanine nucleotide exchange factor. (2201 aa)

Predicted Functional Partners:

ENSAPLP00000023562

0.919

DAPK2

0.793

CDC42

0.755

DAPK3

0.738

RAC1

0.725

RAC3

0.725

RAC2

0.725

STK17A

0.721

STK17B

0.692

ITSN2

0.665

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	ENSAPLP00000023562	ENSAPLP00000021122	ENSAPLP00000023562	Cell division cycle 42.	Protein kinase domain-containing protein.	0.755
CDC42	ITSN2	ENSAPLP00000021122	ENSAPLP00000030081	Cell division cycle 42.	Uncharacterized protein.	0.880
CDC42	RAC1	ENSAPLP00000021122	ENSAPLP00000003050	Cell division cycle 42.	Rac family small GTPase 1.	0.980
CDC42	RAC2	ENSAPLP00000021122	ENSAPLP00000016104	Cell division cycle 42.	Rac family small GTPase 2.	0.979
CDC42	RAC3	ENSAPLP00000021122	ENSAPLP00000015874	Cell division cycle 42.	Rac family small GTPase 3.	0.806
CDC42	TRIO	ENSAPLP00000021122	ENSAPLP00000008306	Cell division cycle 42.	Trio Rho guanine nucleotide exchange factor.	0.755
DAPK2	DAPK3	ENSAPLP00000030409	ENSAPLP00000021440	Death associated protein kinase 2.	Death associated protein kinase 3.	0.904
DAPK2	TRIO	ENSAPLP00000030409	ENSAPLP00000008306	Death associated protein kinase 2.	Trio Rho guanine nucleotide exchange factor.	0.793
DAPK3	DAPK2	ENSAPLP00000021440	ENSAPLP00000030409	Death associated protein kinase 3.	Death associated protein kinase 2.	0.904
DAPK3	TRIO	ENSAPLP00000021440	ENSAPLP00000008306	Death associated protein kinase 3.	Trio Rho guanine nucleotide exchange factor.	0.738
ENSAPLP00000023562	CDC42	ENSAPLP00000023562	ENSAPLP00000021122	Protein kinase domain-containing protein.	Cell division cycle 42.	0.755
ENSAPLP00000023562	ITSN2	ENSAPLP00000023562	ENSAPLP00000030081	Protein kinase domain-containing protein.	Uncharacterized protein.	0.665
ENSAPLP00000023562	RAC1	ENSAPLP00000023562	ENSAPLP00000003050	Protein kinase domain-containing protein.	Rac family small GTPase 1.	0.725
ENSAPLP00000023562	RAC2	ENSAPLP00000023562	ENSAPLP00000016104	Protein kinase domain-containing protein.	Rac family small GTPase 2.	0.725
ENSAPLP00000023562	RAC3	ENSAPLP00000023562	ENSAPLP00000015874	Protein kinase domain-containing protein.	Rac family small GTPase 3.	0.725
ENSAPLP00000023562	TRIO	ENSAPLP00000023562	ENSAPLP00000008306	Protein kinase domain-containing protein.	Trio Rho guanine nucleotide exchange factor.	0.919
ITSN2	CDC42	ENSAPLP00000030081	ENSAPLP00000021122	Uncharacterized protein.	Cell division cycle 42.	0.880
ITSN2	ENSAPLP00000023562	ENSAPLP00000030081	ENSAPLP00000023562	Uncharacterized protein.	Protein kinase domain-containing protein.	0.665
ITSN2	RAC1	ENSAPLP00000030081	ENSAPLP00000003050	Uncharacterized protein.	Rac family small GTPase 1.	0.760
ITSN2	RAC2	ENSAPLP00000030081	ENSAPLP00000016104	Uncharacterized protein.	Rac family small GTPase 2.	0.760