STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APPAmyloid beta precursor protein. (717 aa)    
Predicted Functional Partners:
PSEN1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 
 0.995
APLP2
Amyloid beta precursor like protein 2.
   
  0.977
SNCA
Alpha-synuclein; Belongs to the synuclein family.
    
 0.965
PSEN2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 
 0.957
APBA2
Amyloid beta precursor protein binding family A member 2.
   
 
 0.951
ENSAPLP00000028418
Uncharacterized protein.
    
 0.949
ENSAPLP00000029550
Uncharacterized protein.
    
 0.949
APBA1
Amyloid beta precursor protein binding family A member 1.
   
 
 0.946
NCSTN
Nicastrin.
    
 0.942
BCHE
Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.
    
 0.924
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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