Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
APLFAprataxin and PNKP like factor. (507 aa)    
Predicted Functional Partners:
ENSAPLP00000028415
XRCC1_N domain-containing protein.
    
 
 0.979
LIG3
DNA ligase.
    
 
 0.978
LIG4
DNA ligase.
    
 
 0.972
XRCC6
X-ray repair cross complementing 6.
    
 
 0.971
XRCC5
X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.
    
 
 0.963
CHD1L
Chromodomain helicase DNA binding protein 1 like.
    
 
 0.948
TDP1
Tyrosyl-DNA phosphodiesterase 1.
    
 
 0.937
XPC
XPC complex subunit, DNA damage recognition and repair factor.
    
 
 0.913
SUPT16H
SPT16 homolog, facilitates chromatin remodeling subunit.
    
 
 0.895
PARP1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
    
 
 0.886
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
Server load: low (16%) [HD]