Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CCN2Cellular communication network factor 2. (347 aa)    
Predicted Functional Partners:
U3I3U9_ANAPP
Uncharacterized protein.
  
  
 
0.902
TGFB2
Transforming growth factor beta; Belongs to the TGF-beta family.
      
 0.694
LATS1
Large tumor suppressor kinase 1.
      
 0.595
ANKRD1
Ankyrin repeat domain 1.
    
 
 0.589
IL6
Uncharacterized protein.
   
  
 0.549
EDN1
Endothelin 1.
      
 0.545
LATS2
Non-specific serine/threonine protein kinase.
      
 0.525
SMAD7
Mothers against decapentaplegic homolog.
      
 0.483
SMAD4
Mothers against decapentaplegic homolog.
      
 0.481
FGF1
Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]
      
 0.473
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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