MTHFR protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

MTHFR

Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (651 aa)

Predicted Functional Partners:

MTR

0.997

SHMT2

0.991

GLDC

0.988

GCSH

0.983

MTHFD1

0.977

TYMS

0.973

U3IG02_ANAPP

0.968

MTHFD2L

0.968

SARDH

0.963

DLD

0.959

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLD	GCSH	ENSAPLP00000009721	ENSAPLP00000029441	Dihydrolipoyl dehydrogenase.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.993
DLD	GLDC	ENSAPLP00000009721	ENSAPLP00000028494	Dihydrolipoyl dehydrogenase.	Glycine decarboxylase.	0.997
DLD	MTHFD1	ENSAPLP00000009721	ENSAPLP00000021022	Dihydrolipoyl dehydrogenase.	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1.	0.915
DLD	MTHFD2L	ENSAPLP00000009721	ENSAPLP00000012653	Dihydrolipoyl dehydrogenase.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.941
DLD	MTHFR	ENSAPLP00000009721	ENSAPLP00000009508	Dihydrolipoyl dehydrogenase.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.959
DLD	MTR	ENSAPLP00000009721	ENSAPLP00000009750	Dihydrolipoyl dehydrogenase.	5-methyltetrahydrofolate-homocysteine methyltransferase.	0.489
DLD	SARDH	ENSAPLP00000009721	ENSAPLP00000006963	Dihydrolipoyl dehydrogenase.	Sarcosine dehydrogenase.	0.591
DLD	SHMT2	ENSAPLP00000009721	ENSAPLP00000003424	Dihydrolipoyl dehydrogenase.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.955
DLD	TYMS	ENSAPLP00000009721	ENSAPLP00000015546	Dihydrolipoyl dehydrogenase.	Thymidylate synthetase.	0.951
DLD	U3IG02_ANAPP	ENSAPLP00000009721	ENSAPLP00000006174	Dihydrolipoyl dehydrogenase.	Uncharacterized protein.	0.941
GCSH	DLD	ENSAPLP00000029441	ENSAPLP00000009721	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Dihydrolipoyl dehydrogenase.	0.993
GCSH	GLDC	ENSAPLP00000029441	ENSAPLP00000028494	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Glycine decarboxylase.	0.999
GCSH	MTHFD1	ENSAPLP00000029441	ENSAPLP00000021022	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1.	0.941
GCSH	MTHFD2L	ENSAPLP00000029441	ENSAPLP00000012653	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.976
GCSH	MTHFR	ENSAPLP00000029441	ENSAPLP00000009508	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.983
GCSH	MTR	ENSAPLP00000029441	ENSAPLP00000009750	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	5-methyltetrahydrofolate-homocysteine methyltransferase.	0.649
GCSH	SARDH	ENSAPLP00000029441	ENSAPLP00000006963	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Sarcosine dehydrogenase.	0.864
GCSH	SHMT2	ENSAPLP00000029441	ENSAPLP00000003424	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.983
GCSH	TYMS	ENSAPLP00000029441	ENSAPLP00000015546	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Thymidylate synthetase.	0.981
GCSH	U3IG02_ANAPP	ENSAPLP00000029441	ENSAPLP00000006174	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Uncharacterized protein.	0.976

page 1 of 6

Server load: low (14%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Co-occurrence

Textmining

Co-expression

© STRING Consortium 2026

Credits

Access

Info

About