Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TOPBP1DNA topoisomerase II binding protein 1. (1469 aa)    
Predicted Functional Partners:
BRCA1
BRCA1 DNA repair associated.
   
 0.993
TICRR
TOPBP1 interacting checkpoint and replication regulator.
    
 
 0.992
BARD1
BRCA1 associated RING domain 1.
   
 0.991
BRIP1
Helicase ATP-binding domain-containing protein.
   
 0.990
ATRIP
ATR interacting protein.
    
 0.989
CLSPN
Claspin.
   
 0.987
E2F1
E2F transcription factor 1.
    
 
 0.972
RAD17
RAD17 checkpoint clamp loader component.
   
 0.970
RAD9A
RAD9 checkpoint clamp component A.
    
 0.961
HUS1
Checkpoint protein; Belongs to the HUS1 family.
    
 0.954
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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