Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)    
Predicted Functional Partners:
ORC1
Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
   
0.999
ORC3
Origin recognition complex subunit 3.
   
 0.999
ORC5
Origin recognition complex subunit 5.
   
 0.999
CDT1
Chromatin licensing and DNA replication factor 1.
   
 0.998
ORC6
Uncharacterized protein.
   
 0.997
MCM3
DNA helicase; Belongs to the MCM family.
   
 0.992
MCM10
Minichromosome maintenance 10 replication initiation factor.
    
 0.990
ENSAPLP00000030611
Uncharacterized protein.
   
 0.988
LRWD1
Leucine rich repeats and WD repeat domain containing 1.
    
 0.987
DBF4
DBF4 zinc finger.
    
 0.985
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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