Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PARK7Parkinsonism associated deglycase. (183 aa)    
Predicted Functional Partners:
PRKN
Parkin RBR E3 ubiquitin protein ligase.
    
 0.989
SNCA
Alpha-synuclein; Belongs to the synuclein family.
    
 
 0.970
PINK1
PTEN induced kinase 1.
    
 
 0.954
SOD3
Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.
  
 0.904
SOD1
Superoxide dismutase 1.
  
 0.904
ATP13A2
Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
     
 0.875
SOD2
Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
   
 0.860
TPI1
Triosephosphate isomerase.
  
 
 0.844
VPS35
Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.
      
 0.813
HSPA4
Heat shock protein family A (Hsp70) member 4.
  
 0.809
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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