PIAS4 protein (Anas platyrhynchos) - STRING interaction network

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Score

PIAS4

Protein inhibitor of activated STAT 4. (485 aa)

Predicted Functional Partners:

UBE2I

0.991

RNF168

0.976

SUMO1

0.965

PIAS1

0.941

PIAS2

0.935

SUMO2

0.935

ENSAPLP00000029099

0.917

BRCA1

0.860

RNF8

0.841

PARP1

0.830

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	ENSAPLP00000029099	ENSAPLP00000026654	ENSAPLP00000029099	BRCA1 DNA repair associated.	Ubiquitin-like domain-containing protein.	0.754
BRCA1	PARP1	ENSAPLP00000026654	ENSAPLP00000014006	BRCA1 DNA repair associated.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.844
BRCA1	PIAS1	ENSAPLP00000026654	ENSAPLP00000001980	BRCA1 DNA repair associated.	Uncharacterized protein.	0.684
BRCA1	PIAS2	ENSAPLP00000026654	ENSAPLP00000004785	BRCA1 DNA repair associated.	Protein inhibitor of activated STAT 2.	0.563
BRCA1	PIAS4	ENSAPLP00000026654	ENSAPLP00000010609	BRCA1 DNA repair associated.	Protein inhibitor of activated STAT 4.	0.860
BRCA1	RNF168	ENSAPLP00000026654	ENSAPLP00000015131	BRCA1 DNA repair associated.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]	0.931
BRCA1	RNF8	ENSAPLP00000026654	ENSAPLP00000014631	BRCA1 DNA repair associated.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.780
BRCA1	SUMO1	ENSAPLP00000026654	ENSAPLP00000022646	BRCA1 DNA repair associated.	Small ubiquitin like modifier 1.	0.825
BRCA1	SUMO2	ENSAPLP00000026654	ENSAPLP00000006410	BRCA1 DNA repair associated.	Small ubiquitin-related modifier.	0.754
BRCA1	UBE2I	ENSAPLP00000026654	ENSAPLP00000016007	BRCA1 DNA repair associated.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.846
ENSAPLP00000029099	BRCA1	ENSAPLP00000029099	ENSAPLP00000026654	Ubiquitin-like domain-containing protein.	BRCA1 DNA repair associated.	0.754
ENSAPLP00000029099	PARP1	ENSAPLP00000029099	ENSAPLP00000014006	Ubiquitin-like domain-containing protein.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.661
ENSAPLP00000029099	PIAS1	ENSAPLP00000029099	ENSAPLP00000001980	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.685
ENSAPLP00000029099	PIAS2	ENSAPLP00000029099	ENSAPLP00000004785	Ubiquitin-like domain-containing protein.	Protein inhibitor of activated STAT 2.	0.882
ENSAPLP00000029099	PIAS4	ENSAPLP00000029099	ENSAPLP00000010609	Ubiquitin-like domain-containing protein.	Protein inhibitor of activated STAT 4.	0.917
ENSAPLP00000029099	RNF168	ENSAPLP00000029099	ENSAPLP00000015131	Ubiquitin-like domain-containing protein.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]	0.502
ENSAPLP00000029099	RNF8	ENSAPLP00000029099	ENSAPLP00000014631	Ubiquitin-like domain-containing protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.490
ENSAPLP00000029099	SUMO1	ENSAPLP00000029099	ENSAPLP00000022646	Ubiquitin-like domain-containing protein.	Small ubiquitin like modifier 1.	0.741
ENSAPLP00000029099	UBE2I	ENSAPLP00000029099	ENSAPLP00000016007	Ubiquitin-like domain-containing protein.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.958
PARP1	BRCA1	ENSAPLP00000014006	ENSAPLP00000026654	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	BRCA1 DNA repair associated.	0.844