Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CISD1CDGSH iron sulfur domain 1. (116 aa)    
Predicted Functional Partners:
PRKN
Parkin RBR E3 ubiquitin protein ligase.
    
 
 0.712
DDB1
Damage specific DNA binding protein 1.
    
 
 0.692
CARS1
Cysteinyl-tRNA synthetase.
      
 0.674
CARS2
Cysteinyl-tRNA synthetase 2, mitochondrial.
      
 0.666
TOMM70
TPR_REGION domain-containing protein.
      
 0.666
IREB2
Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family.
   
 
 0.612
HSBP1
Heat shock factor binding protein 1.
      
 0.580
ATP5MG
ATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...]
   
  
 0.576
DDA1
DET1 and DDB1 associated 1.
    
 
 0.571
UBQLN4
Ubiquilin 4.
      
 0.547
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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