STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLP1Proteolipid protein 1. (259 aa)    
Predicted Functional Partners:
MBP
Myelin basic protein.
   
 
 0.819
SOX10
SRY-box transcription factor 10.
   
  
 0.737
U3IS84_ANAPP
IF rod domain-containing protein; Belongs to the intermediate filament family.
   
 
 0.660
GFAP
IF rod domain-containing protein; Belongs to the intermediate filament family.
   
 
 0.660
GJC2
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
   
  
 0.629
MPZ
Myelin protein zero.
   
  
 0.629
OLIG2
Oligodendrocyte transcription factor 2.
   
  
 0.614
OLIG3
Oligodendrocyte transcription factor 3.
   
  
 0.614
PDGFRA
Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.
      
 0.611
USP1
Ubiquitin specific peptidase 1; Belongs to the peptidase C19 family.
      
 0.610
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.