U3IWK3_ANAPP protein (Anas platyrhynchos) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

U3IWK3_ANAPP

Uncharacterized protein. (578 aa)

Predicted Functional Partners:

INPP5J

0.910

ENSAPLP00000026276

0.900

ENSAPLP00000021662

0.899

SACM1L

0.766

SH3GL2

0.739

SH3GL1

0.736

SH3GL3

0.736

ENSAPLP00000020757

0.728

ENSAPLP00000024521

0.728

ENSAPLP00000028453

0.728

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAPLP00000020757	ENSAPLP00000021662	ENSAPLP00000020757	ENSAPLP00000021662	Uncharacterized protein.	Uncharacterized protein.	0.728
ENSAPLP00000020757	ENSAPLP00000024521	ENSAPLP00000020757	ENSAPLP00000024521	Uncharacterized protein.	EH domain-containing protein.	0.925
ENSAPLP00000020757	ENSAPLP00000026276	ENSAPLP00000020757	ENSAPLP00000026276	Uncharacterized protein.	SAC domain-containing protein.	0.728
ENSAPLP00000020757	ENSAPLP00000028453	ENSAPLP00000020757	ENSAPLP00000028453	Uncharacterized protein.	annotation not available	0.925
ENSAPLP00000020757	U3IWK3_ANAPP	ENSAPLP00000020757	ENSAPLP00000011629	Uncharacterized protein.	Uncharacterized protein.	0.728
ENSAPLP00000021662	ENSAPLP00000020757	ENSAPLP00000021662	ENSAPLP00000020757	Uncharacterized protein.	Uncharacterized protein.	0.728
ENSAPLP00000021662	ENSAPLP00000024521	ENSAPLP00000021662	ENSAPLP00000024521	Uncharacterized protein.	EH domain-containing protein.	0.728
ENSAPLP00000021662	ENSAPLP00000026276	ENSAPLP00000021662	ENSAPLP00000026276	Uncharacterized protein.	SAC domain-containing protein.	0.919
ENSAPLP00000021662	ENSAPLP00000028453	ENSAPLP00000021662	ENSAPLP00000028453	Uncharacterized protein.	annotation not available	0.728
ENSAPLP00000021662	INPP5J	ENSAPLP00000021662	ENSAPLP00000012277	Uncharacterized protein.	IPPc domain-containing protein.	0.602
ENSAPLP00000021662	SACM1L	ENSAPLP00000021662	ENSAPLP00000028685	Uncharacterized protein.	SAC1 like phosphatidylinositide phosphatase.	0.478
ENSAPLP00000021662	SH3GL1	ENSAPLP00000021662	ENSAPLP00000001995	Uncharacterized protein.	SH3 domain containing GRB2 like 1, endophilin A2.	0.736
ENSAPLP00000021662	SH3GL2	ENSAPLP00000021662	ENSAPLP00000006849	Uncharacterized protein.	SH3 domain containing GRB2 like 2, endophilin A1.	0.739
ENSAPLP00000021662	SH3GL3	ENSAPLP00000021662	ENSAPLP00000005571	Uncharacterized protein.	SH3 domain containing GRB2 like 3, endophilin A3.	0.736
ENSAPLP00000021662	U3IWK3_ANAPP	ENSAPLP00000021662	ENSAPLP00000011629	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSAPLP00000024521	ENSAPLP00000020757	ENSAPLP00000024521	ENSAPLP00000020757	EH domain-containing protein.	Uncharacterized protein.	0.925
ENSAPLP00000024521	ENSAPLP00000021662	ENSAPLP00000024521	ENSAPLP00000021662	EH domain-containing protein.	Uncharacterized protein.	0.728
ENSAPLP00000024521	ENSAPLP00000026276	ENSAPLP00000024521	ENSAPLP00000026276	EH domain-containing protein.	SAC domain-containing protein.	0.728
ENSAPLP00000024521	ENSAPLP00000028453	ENSAPLP00000024521	ENSAPLP00000028453	EH domain-containing protein.	annotation not available	0.925
ENSAPLP00000024521	U3IWK3_ANAPP	ENSAPLP00000024521	ENSAPLP00000011629	EH domain-containing protein.	Uncharacterized protein.	0.728

page 1 of 3

Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

11 of 41

1.98

6.18

1.06e-18

GO:0000160

Phosphorelay signal transduction system

10 of 34

2.02

6.02

4.17e-17

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

8 of 13

2.34

6.34

1.92e-14

GO:0016772

Transferase activity, transferring phosphorus-containing groups

9 of 133

1.38

2.28

4.31e-10

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

9 of 760

0.62

0.48

0.0023

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2926

Two-component regulatory system, and Histidine kinase domain

10 of 23

2.18

7.21

1.41e-18

CL:2928

Two-component regulatory system, and Histidine kinase domain

9 of 18

2.25

6.93

6.92e-17

CL:2931

Two-component regulatory system, and PAS domain

8 of 12

2.37

6.82

1.80e-15

CL:2923

Phosphorelay signal transduction system, and P-type ion transporter activity

11 of 35

2.04

6.74

1.59e-19

CL:2933

Histidine kinase domain, and Transcriptional regulatory protein, C terminal

3 of 5

2.32

2.12

9.31e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aka02020

Two-component system

4 of 79

1.25

0.87

0.0063

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

9 of 67

1.67

3.58

2.78e-12

KW-0902

Two-component regulatory system

4 of 14

2.0

2.46

7.00e-06

KW-0067

ATP-binding

6 of 232

0.96

0.81

0.00089

KW-0597

Phosphoprotein

2 of 22

1.51

0.67

0.0435

KW-1133

Transmembrane helix

8 of 684

0.61

0.47

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005467

Histidine kinase domain

9 of 11

2.46

7.81

2.22e-17

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

9 of 12

2.42

7.7

2.22e-17

IPR003594

Histidine kinase/HSP90-like ATPase

9 of 12

2.42

7.7

2.22e-17

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

8 of 11

2.41

6.82

3.22e-15

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

8 of 11

2.41

6.82

3.22e-15

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00387

Histidine kinase-like ATPases

9 of 11

2.46

8.28

1.41e-18

SM00388

His Kinase A (phosphoacceptor) domain

8 of 11

2.41

7.18

4.08e-16

SM00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain

4 of 4

2.55

3.75

6.79e-08

SM00091

PAS domain

2 of 3

2.37

1.52

0.0015

SM00862

Transcriptional regulatory protein, C terminal

2 of 12

1.77

0.99

0.0109

(more ...)

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