STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (475 aa)    
Predicted Functional Partners:
MDM2
Uncharacterized protein.
    
0.990
ENSAPLP00000026542
SWIB domain-containing protein.
    
0.949
RPS27A
Ubiquitin-like domain-containing protein.
    
 0.877
USP7
Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.
    
 0.845
ENSAPLP00000025536
Ubiquitin-like domain-containing protein.
    
 0.805
ATM
Non-specific serine/threonine protein kinase.
   
 0.785
ENSAPLP00000023897
Uncharacterized protein.
    
 0.772
CHEK2
Checkpoint kinase 2.
    
 0.718
RPL11
Ribosomal protein L11.
    
 
 0.705
TP73
Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
    
 0.696
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.