STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTCH1Patched 1. (1412 aa)    
Predicted Functional Partners:
SHH
Sonic hedgehog signaling molecule.
   
 0.999
CDON
Cell adhesion associated, oncogene regulated.
    
 0.997
IHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.995
SMO
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.994
BOC
BOC cell adhesion associated, oncogene regulated.
    
 0.989
SMURF1
E3 ubiquitin-protein ligase.
    
 0.968
DHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.962
GLI1
GLI family zinc finger 1.
   
 0.960
GLI2
Uncharacterized protein.
   
 0.943
PTCH2
SSD domain-containing protein.
  
  
0.922
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.