KLF15 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

KLF15

Kruppel like factor 15. (403 aa)

Predicted Functional Partners:

SP1

0.628

ZNF414

0.611

CEBPB

0.548

SERTAD2

0.546

NR1H4

0.454

SIRT1

0.446

CACUL1

0.412

KBTBD12

0.403

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACUL1	KLF15	ENSAPLP00000006071	ENSAPLP00000012754	CDK2 associated cullin domain 1; Belongs to the cullin family.	Kruppel like factor 15.	0.412
CEBPB	KLF15	ENSAPLP00000021900	ENSAPLP00000012754	CCAAT/enhancer-binding protein.	Kruppel like factor 15.	0.548
CEBPB	SP1	ENSAPLP00000021900	ENSAPLP00000027518	CCAAT/enhancer-binding protein.	Sp1 transcription factor.	0.488
KBTBD12	KLF15	ENSAPLP00000005186	ENSAPLP00000012754	Kelch repeat and BTB domain containing 12.	Kruppel like factor 15.	0.403
KLF15	CACUL1	ENSAPLP00000012754	ENSAPLP00000006071	Kruppel like factor 15.	CDK2 associated cullin domain 1; Belongs to the cullin family.	0.412
KLF15	CEBPB	ENSAPLP00000012754	ENSAPLP00000021900	Kruppel like factor 15.	CCAAT/enhancer-binding protein.	0.548
KLF15	KBTBD12	ENSAPLP00000012754	ENSAPLP00000005186	Kruppel like factor 15.	Kelch repeat and BTB domain containing 12.	0.403
KLF15	NR1H4	ENSAPLP00000012754	ENSAPLP00000013117	Kruppel like factor 15.	Nuclear receptor subfamily 1 group H member 4.	0.454
KLF15	SERTAD2	ENSAPLP00000012754	ENSAPLP00000000077	Kruppel like factor 15.	SERTA domain containing 2.	0.546
KLF15	SIRT1	ENSAPLP00000012754	ENSAPLP00000030709	Kruppel like factor 15.	Sirtuin 1.	0.446
KLF15	SP1	ENSAPLP00000012754	ENSAPLP00000027518	Kruppel like factor 15.	Sp1 transcription factor.	0.628
KLF15	ZNF414	ENSAPLP00000012754	ENSAPLP00000018907	Kruppel like factor 15.	Zinc finger protein 414.	0.611
NR1H4	KLF15	ENSAPLP00000013117	ENSAPLP00000012754	Nuclear receptor subfamily 1 group H member 4.	Kruppel like factor 15.	0.454
SERTAD2	KLF15	ENSAPLP00000000077	ENSAPLP00000012754	SERTA domain containing 2.	Kruppel like factor 15.	0.546
SIRT1	KLF15	ENSAPLP00000030709	ENSAPLP00000012754	Sirtuin 1.	Kruppel like factor 15.	0.446
SP1	CEBPB	ENSAPLP00000027518	ENSAPLP00000021900	Sp1 transcription factor.	CCAAT/enhancer-binding protein.	0.488
SP1	KLF15	ENSAPLP00000027518	ENSAPLP00000012754	Sp1 transcription factor.	Kruppel like factor 15.	0.628
ZNF414	KLF15	ENSAPLP00000018907	ENSAPLP00000012754	Zinc finger protein 414.	Kruppel like factor 15.	0.611

Network Stats

number of nodes:

5

number of edges:

7

average node degree:

2.8

avg. local clustering coefficient:

0.767

expected number of edges:

4

PPI enrichment p-value:

0.124

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070330

Aromatase activity

3 of 11

2.61

1.99

0.00021

GO:0020037

Heme binding

4 of 113

1.73

1.42

0.00099

GO:0005506

Iron ion binding

3 of 127

1.55

0.73

0.0319

GO:0003824

Catalytic activity

10 of 5203

0.46

0.31

0.0319

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30660177

(2019) Isolation of blue-green eggshell pigmentation-related genes from Putian duck through RNA-seq.

4 of 25

2.38

2.49

1.79e-05

PMID:33782952

(2021) Antimicrobial prescribing guidelines for poultry.

2 of 2

3.18

1.14

0.0088

PMID:34214746

(2021) Protective effect of glutathione S-transferase enzyme activity against aflatoxin B1 in poultry species: relationship between glutathione S-transferase enzyme kinetic parameters, and resistance to aflatoxin B1.

2 of 5

2.78

0.93

0.0204

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9381

Mixed, incl. Sulfation, and Epoxygenase P450 pathway

4 of 23

2.42

2.71

6.67e-06

CL:9383

Sulfation, and Epoxygenase P450 pathway

3 of 8

2.75

2.28

6.55e-05

CL:8025

Cytochrome P450, E-class, CYP3A, and Cytochrome P450, E-class, group I, CYP1

2 of 5

2.78

1.1

0.0103

CL:8590

Protoporphyrinogen IX biosynthetic process, and Heme transport

2 of 12

2.4

0.81

0.0333

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla00591

Linoleic acid metabolism

2 of 13

2.37

1.17

0.0069

apla00980

Metabolism of xenobiotics by cytochrome P450

2 of 22

2.14

1.09

0.0090

apla00830

Retinol metabolism

2 of 23

2.12

1.09

0.0090

apla00140

Steroid hormone biosynthesis

2 of 27

2.05

1.08

0.0090

apla01100

Metabolic pathways

5 of 996

0.88

0.61

0.0090

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-211859

Biological oxidations

8 of 192

1.8

3.67

1.02e-10

MAP-9749641

Aspirin ADME

4 of 21

2.46

3.12

1.09e-06

MAP-5423646

Aflatoxin activation and detoxification

3 of 14

2.51

2.19

8.12e-05

MAP-9757110

Prednisone ADME

3 of 20

2.36

2.11

0.00010

MAP-156580

Phase II - Conjugation of compounds

4 of 77

1.89

1.95

8.12e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0503

Monooxygenase

3 of 43

2.02

1.53

0.0010

KW-0349

Heme

3 of 60

1.88

1.43

0.0013

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00067

Cytochrome P450

3 of 45

2.0

1.12

0.0071

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008072

Cytochrome P450, E-class, CYP3A

2 of 2

3.18

1.07

0.0118

IPR002402

Cytochrome P450, E-class, group II

2 of 2

3.18

1.07

0.0118

IPR017972

Cytochrome P450, conserved site

3 of 36

2.1

1.02

0.0118

IPR036396

Cytochrome P450 superfamily

3 of 46

1.99

1.01

0.0118

IPR001128

Cytochrome P450

3 of 45

2.0

1.01

0.0118

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2024

Credits

Access

Info

About