STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (625 aa)    
Predicted Functional Partners:
PLK1
Serine/threonine-protein kinase PLK.
   
 
  0.884
BUB1B
Uncharacterized protein.
   
 
  0.643
CDC20
Cell division cycle 20.
   
 
  0.628
CDC20B
Cell division cycle 20B.
   
 
  0.628
PLK2
Serine/threonine-protein kinase PLK.
   
 
  0.536
ECT2
Epithelial cell transforming 2.
  
    0.532
NDC80
NDC80 kinetochore complex component.
   
 
  0.480
PLK4
Polo like kinase 4.
   
 
 0.459
MAD2L1
Mitotic arrest deficient 2 like 1.
   
 
  0.458
FZR1
Fizzy and cell division cycle 20 related 1.
   
 
  0.434
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.