CFAP61 protein (Anas platyrhynchos) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

CFAP61

Cilia and flagella associated protein 61. (1117 aa)

Predicted Functional Partners:

CFAP58

0.544

MAATS1

0.500

CFAP43

0.485

CRNKL1

0.440

CCDC127

0.439

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC127	CFAP61	ENSAPLP00000020199	ENSAPLP00000013263	Coiled-coil domain containing 127.	Cilia and flagella associated protein 61.	0.439
CFAP43	CFAP58	ENSAPLP00000005592	ENSAPLP00000005302	Cilia and flagella associated protein 43.	Cilia and flagella associated protein 58.	0.473
CFAP43	CFAP61	ENSAPLP00000005592	ENSAPLP00000013263	Cilia and flagella associated protein 43.	Cilia and flagella associated protein 61.	0.485
CFAP43	MAATS1	ENSAPLP00000005592	ENSAPLP00000010752	Cilia and flagella associated protein 43.	CFAP91 domain-containing protein.	0.435
CFAP58	CFAP43	ENSAPLP00000005302	ENSAPLP00000005592	Cilia and flagella associated protein 58.	Cilia and flagella associated protein 43.	0.473
CFAP58	CFAP61	ENSAPLP00000005302	ENSAPLP00000013263	Cilia and flagella associated protein 58.	Cilia and flagella associated protein 61.	0.544
CFAP58	MAATS1	ENSAPLP00000005302	ENSAPLP00000010752	Cilia and flagella associated protein 58.	CFAP91 domain-containing protein.	0.453
CFAP61	CCDC127	ENSAPLP00000013263	ENSAPLP00000020199	Cilia and flagella associated protein 61.	Coiled-coil domain containing 127.	0.439
CFAP61	CFAP43	ENSAPLP00000013263	ENSAPLP00000005592	Cilia and flagella associated protein 61.	Cilia and flagella associated protein 43.	0.485
CFAP61	CFAP58	ENSAPLP00000013263	ENSAPLP00000005302	Cilia and flagella associated protein 61.	Cilia and flagella associated protein 58.	0.544
CFAP61	CRNKL1	ENSAPLP00000013263	ENSAPLP00000012928	Cilia and flagella associated protein 61.	Crooked neck pre-mRNA splicing factor 1.	0.440
CFAP61	MAATS1	ENSAPLP00000013263	ENSAPLP00000010752	Cilia and flagella associated protein 61.	CFAP91 domain-containing protein.	0.500
CRNKL1	CFAP61	ENSAPLP00000012928	ENSAPLP00000013263	Crooked neck pre-mRNA splicing factor 1.	Cilia and flagella associated protein 61.	0.440
MAATS1	CFAP43	ENSAPLP00000010752	ENSAPLP00000005592	CFAP91 domain-containing protein.	Cilia and flagella associated protein 43.	0.435
MAATS1	CFAP58	ENSAPLP00000010752	ENSAPLP00000005302	CFAP91 domain-containing protein.	Cilia and flagella associated protein 58.	0.453
MAATS1	CFAP61	ENSAPLP00000010752	ENSAPLP00000013263	CFAP91 domain-containing protein.	Cilia and flagella associated protein 61.	0.500

Network Stats

number of nodes:

11

number of edges:

14

average node degree:

2.55

avg. local clustering coefficient:

0.887

expected number of edges:

10

PPI enrichment p-value:

0.144

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044772

Mitotic cell cycle phase transition

6 of 120

1.96

3.11

1.08e-07

GO:1905786

Positive regulation of anaphase-promoting complex-dependent catabolic process

3 of 3

3.26

3.06

2.90e-06

GO:0031145

Anaphase-promoting complex-dependent catabolic process

3 of 19

2.46

2.18

8.35e-05

GO:0000079

Regulation of cyclin-dependent protein serine/threonine kinase activity

4 of 73

2.0

2.16

3.82e-05

GO:0031396

Regulation of protein ubiquitination

5 of 171

1.73

2.06

1.76e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990757

Ubiquitin ligase activator activity

3 of 4

3.14

2.7

1.26e-05

GO:0010997

Anaphase-promoting complex binding

3 of 9

2.79

2.56

1.98e-05

GO:0016538

Cyclin-dependent protein serine/threonine kinase regulator activity

4 of 51

2.16

2.4

1.70e-05

GO:0043125

ErbB-3 class receptor binding

2 of 4

2.96

1.63

0.0011

GO:0030549

Acetylcholine receptor activator activity

2 of 4

2.96

1.63

0.0011

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000307

Cyclin-dependent protein kinase holoenzyme complex

6 of 51

2.33

4.66

2.70e-10

GO:0005680

Anaphase-promoting complex

3 of 21

2.42

2.26

5.31e-05

GO:1990234

Transferase complex

9 of 815

1.31

1.96

7.84e-09

GO:0016533

Protein kinase 5 complex

2 of 4

2.96

1.77

0.00062

GO:0031461

cullin-RING ubiquitin ligase complex

4 of 177

1.62

1.51

0.00037

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8864

Cell cycle, and Regulation of APC/C activators between G1/S and early anaphase

4 of 77

1.98

1.72

0.00035

CL:8865

Cell cycle, and Regulation of APC/C activators between G1/S and early anaphase

3 of 69

1.9

0.94

0.0158

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-176417

Phosphorylation of Emi1

2 of 7

2.72

1.12

0.0094

CFA-174113

SCF-beta-TrCP mediated degradation of Emi1

2 of 8

2.66

1.12

0.0094

CFA-69656

Cyclin A:Cdk2-associated events at S phase entry

3 of 65

1.93

1.05

0.0094

CFA-176407

Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase

2 of 20

2.26

0.9

0.0220

CFA-69231

Cyclin D associated events in G1

2 of 38

1.99

0.76

0.0370

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0195

Cyclin

3 of 34

2.21

1.79

0.00038

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00385

Domain present in cyclins, TFIIB and Retinoblastoma

3 of 42

2.12

1.49

0.0014

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