ADAM10 protein (Anas platyrhynchos) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

ADAM10

ADAM metallopeptidase domain 10. (711 aa)

Predicted Functional Partners:

CDH1

0.804

EFNA2

0.762

DLL1

0.747

NOTCH2

0.732

SFRP2

0.713

CD2AP

0.706

CDH2

0.660

CDH6

0.652

PSEN1

0.646

TSPAN14

0.641

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM10	CD2AP	ENSAPLP00000013418	ENSAPLP00000023392	ADAM metallopeptidase domain 10.	CD2 associated protein.	0.706
ADAM10	CDH1	ENSAPLP00000013418	ENSAPLP00000019488	ADAM metallopeptidase domain 10.	Uncharacterized protein.	0.804
ADAM10	CDH2	ENSAPLP00000013418	ENSAPLP00000003812	ADAM metallopeptidase domain 10.	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	0.660
ADAM10	CDH6	ENSAPLP00000013418	ENSAPLP00000016368	ADAM metallopeptidase domain 10.	Cadherin 6; Cadherins are calcium-dependent cell adhesion proteins.	0.652
ADAM10	DLL1	ENSAPLP00000013418	ENSAPLP00000011451	ADAM metallopeptidase domain 10.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.747
ADAM10	EFNA2	ENSAPLP00000013418	ENSAPLP00000019515	ADAM metallopeptidase domain 10.	Ephrin A2; Belongs to the ephrin family.	0.762
ADAM10	NOTCH2	ENSAPLP00000013418	ENSAPLP00000021524	ADAM metallopeptidase domain 10.	Notch receptor 2.	0.732
ADAM10	PSEN1	ENSAPLP00000013418	ENSAPLP00000018025	ADAM metallopeptidase domain 10.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.646
ADAM10	SFRP2	ENSAPLP00000013418	ENSAPLP00000029193	ADAM metallopeptidase domain 10.	Secreted frizzled related protein 2.	0.713
ADAM10	TSPAN14	ENSAPLP00000013418	ENSAPLP00000027094	ADAM metallopeptidase domain 10.	Tetraspanin 14; Belongs to the tetraspanin (TM4SF) family.	0.641
CD2AP	ADAM10	ENSAPLP00000023392	ENSAPLP00000013418	CD2 associated protein.	ADAM metallopeptidase domain 10.	0.706
CDH1	ADAM10	ENSAPLP00000019488	ENSAPLP00000013418	Uncharacterized protein.	ADAM metallopeptidase domain 10.	0.804
CDH1	CDH2	ENSAPLP00000019488	ENSAPLP00000003812	Uncharacterized protein.	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	0.868
CDH1	PSEN1	ENSAPLP00000019488	ENSAPLP00000018025	Uncharacterized protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.686
CDH2	ADAM10	ENSAPLP00000003812	ENSAPLP00000013418	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	ADAM metallopeptidase domain 10.	0.660
CDH2	CDH1	ENSAPLP00000003812	ENSAPLP00000019488	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein.	0.868
CDH2	PSEN1	ENSAPLP00000003812	ENSAPLP00000018025	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.521
CDH6	ADAM10	ENSAPLP00000016368	ENSAPLP00000013418	Cadherin 6; Cadherins are calcium-dependent cell adhesion proteins.	ADAM metallopeptidase domain 10.	0.652
DLL1	ADAM10	ENSAPLP00000011451	ENSAPLP00000013418	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	ADAM metallopeptidase domain 10.	0.747
DLL1	NOTCH2	ENSAPLP00000011451	ENSAPLP00000021524	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.742

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.837

expected number of edges:

13

PPI enrichment p-value:

0.00571

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0048643

Positive regulation of skeletal muscle tissue development

4 of 8

2.88

3.63

2.02e-07

GO:0048743

Positive regulation of skeletal muscle fiber development

3 of 4

3.05

2.97

4.00e-06

GO:0042693

Muscle cell fate commitment

3 of 12

2.58

2.37

3.83e-05

GO:0045663

Positive regulation of myoblast differentiation

3 of 15

2.48

2.25

6.08e-05

GO:0045165

Cell fate commitment

5 of 150

1.7

2.07

1.25e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070888

E-box binding

4 of 28

2.33

2.77

4.38e-06

GO:0043425

bHLH transcription factor binding

3 of 18

2.4

2.12

0.00010

GO:0046983

Protein dimerization activity

9 of 690

1.29

1.84

5.31e-08

GO:0140297

DNA-binding transcription factor binding

5 of 288

1.42

1.44

0.00015

GO:0000978

RNA polymerase II cis-regulatory region sequence-specific DNA binding

7 of 732

1.16

1.2

6.27e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

7 of 333

1.5

2.12

5.73e-07

GO:0005634

Nucleus

11 of 5262

0.5

0.4

0.0021

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:38003577

(2023) Whole-Transcriptome RNA Sequencing Uncovers the Global Expression Changes and RNA Regulatory Networks in Duck Embryonic Myogenesis.

2 of 6

2.7

1.08

0.0112

PMID:37729680

(2023) Dietary zinc supplementation in breeding pigeons improves the carcass traits of squabs through regulating antioxidant capacity and myogenic regulatory factor expression.

2 of 3

3.0

1.08

0.0112

PMID:37170512

(2023) Current technologies, regulation, and future perspective of animal product analogs - A review.

2 of 4

2.88

1.08

0.0112

PMID:37108828

(2023) Sow-Offspring Diets Supplemented with Probiotics and Synbiotics Are Associated with Offsprings Growth Performance and Meat Quality.

2 of 5

2.78

1.08

0.0112

PMID:36697366

(2023) Genome-wide association studies demonstrate the genes associated with perimysial thickness in ducks.

2 of 4

2.88

1.08

0.0112

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:22056

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and DNA-binding protein inhibitor

7 of 17

2.79

7.53

3.02e-15

CL:21810

DNA-binding transcription factor activity, RNA polymerase II-specific, and DNA-binding protein inhibitor

10 of 162

1.97

5.57

4.34e-16

CL:22058

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and Runx inhibition domain

4 of 11

2.74

3.82

7.45e-08

CL:22080

DNA-binding protein inhibitor, and E-box binding

3 of 5

2.96

2.88

5.56e-06

CL:21814

Mixed, incl. Myogenesis, and Sox developmental protein N-terminal

3 of 34

2.12

1.64

0.00068

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-525793

Myogenesis

7 of 37

2.46

6.11

3.01e-13

MAP-1266738

Developmental Biology

7 of 573

1.27

1.45

1.48e-05

MAP-2559585

Oncogene Induced Senescence

2 of 11

2.44

0.96

0.0172

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005634

Nucleus

9 of 2704

0.7

0.51

0.0050

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12232

Myogenic determination factor 5

2 of 2

3.18

1.3

0.0046

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036638

Helix-loop-helix DNA-binding domain superfamily

6 of 85

2.03

3.29

6.24e-08

IPR011598

Myc-type, basic helix-loop-helix (bHLH) domain

6 of 85

2.03

3.29

6.24e-08

IPR039704

Myogenic factor

3 of 3

3.18

2.79

8.71e-06

IPR002546

Myogenic muscle-specific protein, N-terminal

3 of 3

3.18

2.79

8.71e-06

IPR022032

Myogenic determination factor 5

2 of 2

3.18

1.41

0.0029

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00353

Helix loop helix domain

6 of 89

2.01

3.55

9.76e-09

SM00520

Basic domain in HLH proteins of MYOD family

3 of 3

3.18

3.2

1.57e-06

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