NCOA1 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NCOA1

Nuclear receptor coactivator. (1479 aa)

Predicted Functional Partners:

RXRA

0.953

NCOA2

0.925

PAX3

0.906

ESR1

0.830

NR1H3

0.825

AR

0.818

NR1H4

0.808

CREBBP

0.786

RXRG

0.773

VDR

0.766

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	CREBBP	ENSAPLP00000006185	ENSAPLP00000020073	Androgen receptor.	CREB binding protein.	0.751
AR	ESR1	ENSAPLP00000006185	ENSAPLP00000004132	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.640
AR	NCOA1	ENSAPLP00000006185	ENSAPLP00000013427	Androgen receptor.	Nuclear receptor coactivator.	0.818
AR	NCOA2	ENSAPLP00000006185	ENSAPLP00000029766	Androgen receptor.	Nuclear receptor coactivator.	0.789
CREBBP	AR	ENSAPLP00000020073	ENSAPLP00000006185	CREB binding protein.	Androgen receptor.	0.751
CREBBP	ESR1	ENSAPLP00000020073	ENSAPLP00000004132	CREB binding protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.889
CREBBP	NCOA1	ENSAPLP00000020073	ENSAPLP00000013427	CREB binding protein.	Nuclear receptor coactivator.	0.786
CREBBP	NCOA2	ENSAPLP00000020073	ENSAPLP00000029766	CREB binding protein.	Nuclear receptor coactivator.	0.786
CREBBP	NR1H3	ENSAPLP00000020073	ENSAPLP00000010690	CREB binding protein.	Nuclear receptor subfamily 1 group H member 3.	0.477
CREBBP	NR1H4	ENSAPLP00000020073	ENSAPLP00000013117	CREB binding protein.	Nuclear receptor subfamily 1 group H member 4.	0.475
CREBBP	RXRA	ENSAPLP00000020073	ENSAPLP00000012995	CREB binding protein.	Retinoid X receptor alpha.	0.647
CREBBP	RXRG	ENSAPLP00000020073	ENSAPLP00000029653	CREB binding protein.	NR LBD domain-containing protein.	0.647
CREBBP	VDR	ENSAPLP00000020073	ENSAPLP00000004646	CREB binding protein.	Vitamin D receptor.	0.441
ESR1	AR	ENSAPLP00000004132	ENSAPLP00000006185	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Androgen receptor.	0.640
ESR1	CREBBP	ENSAPLP00000004132	ENSAPLP00000020073	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	CREB binding protein.	0.889
ESR1	NCOA1	ENSAPLP00000004132	ENSAPLP00000013427	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.830
ESR1	NCOA2	ENSAPLP00000004132	ENSAPLP00000029766	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.808
NCOA1	AR	ENSAPLP00000013427	ENSAPLP00000006185	Nuclear receptor coactivator.	Androgen receptor.	0.818
NCOA1	CREBBP	ENSAPLP00000013427	ENSAPLP00000020073	Nuclear receptor coactivator.	CREB binding protein.	0.786
NCOA1	ESR1	ENSAPLP00000013427	ENSAPLP00000004132	Nuclear receptor coactivator.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.830