DDO protein (Anas platyrhynchos) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

DDO

D-aspartate oxidase. (260 aa)

Predicted Functional Partners:

GOT1

0.937

GOT2

0.919

NIT2

0.913

DAO

0.903

IL4I1

0.902

IDH1

0.865

IDH2

0.865

IDH3A

0.816

MDH1

0.815

OGDHL

0.815

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DAO	DDO	ENSAPLP00000023195	ENSAPLP00000014193	D-amino acid oxidase.	D-aspartate oxidase.	0.903
DDO	DAO	ENSAPLP00000014193	ENSAPLP00000023195	D-aspartate oxidase.	D-amino acid oxidase.	0.903
DDO	GOT1	ENSAPLP00000014193	ENSAPLP00000021568	D-aspartate oxidase.	Aspartate aminotransferase.	0.937
DDO	GOT2	ENSAPLP00000014193	ENSAPLP00000006507	D-aspartate oxidase.	Aspartate aminotransferase.	0.919
DDO	IDH1	ENSAPLP00000014193	ENSAPLP00000014674	D-aspartate oxidase.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.865
DDO	IDH2	ENSAPLP00000014193	ENSAPLP00000021667	D-aspartate oxidase.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.865
DDO	IDH3A	ENSAPLP00000014193	ENSAPLP00000001511	D-aspartate oxidase.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.816
DDO	IL4I1	ENSAPLP00000014193	ENSAPLP00000015917	D-aspartate oxidase.	Amine oxidase.	0.902
DDO	MDH1	ENSAPLP00000014193	ENSAPLP00000009730	D-aspartate oxidase.	Malate dehydrogenase.	0.815
DDO	NIT2	ENSAPLP00000014193	ENSAPLP00000011415	D-aspartate oxidase.	Nitrilase family member 2.	0.913
DDO	OGDHL	ENSAPLP00000014193	ENSAPLP00000012351	D-aspartate oxidase.	Oxoglutarate dehydrogenase like.	0.815
GOT1	DDO	ENSAPLP00000021568	ENSAPLP00000014193	Aspartate aminotransferase.	D-aspartate oxidase.	0.937
GOT1	GOT2	ENSAPLP00000021568	ENSAPLP00000006507	Aspartate aminotransferase.	Aspartate aminotransferase.	0.975
GOT1	IDH1	ENSAPLP00000021568	ENSAPLP00000014674	Aspartate aminotransferase.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.887
GOT1	IDH2	ENSAPLP00000021568	ENSAPLP00000021667	Aspartate aminotransferase.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.886
GOT1	IDH3A	ENSAPLP00000021568	ENSAPLP00000001511	Aspartate aminotransferase.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.860
GOT1	IL4I1	ENSAPLP00000021568	ENSAPLP00000015917	Aspartate aminotransferase.	Amine oxidase.	0.900
GOT1	MDH1	ENSAPLP00000021568	ENSAPLP00000009730	Aspartate aminotransferase.	Malate dehydrogenase.	0.973
GOT1	NIT2	ENSAPLP00000021568	ENSAPLP00000011415	Aspartate aminotransferase.	Nitrilase family member 2.	0.907
GOT1	OGDHL	ENSAPLP00000021568	ENSAPLP00000012351	Aspartate aminotransferase.	Oxoglutarate dehydrogenase like.	0.930

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.866

expected number of edges:

14

PPI enrichment p-value:

1.64e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

6 of 43

2.41

4.56

7.38e-10

GO:0006264

Mitochondrial DNA replication

3 of 11

2.7

2.38

4.02e-05

GO:0106074

aminoacyl-tRNA metabolism involved in translational fidelity

3 of 13

2.63

2.3

5.61e-05

GO:0006419

alanyl-tRNA aminoacylation

2 of 2

3.26

1.79

0.00059

GO:0009059

Macromolecule biosynthetic process

9 of 1607

1.01

1.08

9.67e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

6 of 45

2.39

4.87

1.31e-10

GO:0140640

Catalytic activity, acting on a nucleic acid

10 of 542

1.53

2.99

6.88e-12

GO:0140098

Catalytic activity, acting on RNA

7 of 336

1.58

2.47

7.14e-08

GO:0002161

aminoacyl-tRNA editing activity

3 of 15

2.56

2.35

4.18e-05

GO:0000049

tRNA binding

4 of 94

1.89

1.99

6.27e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017101

aminoacyl-tRNA synthetase multienzyme complex

3 of 12

2.66

2.21

8.39e-05

GO:0005760

Gamma DNA polymerase complex

2 of 3

3.09

1.64

0.0011

GO:0042645

Mitochondrial nucleoid

3 of 40

2.14

1.54

0.0011

GO:0005739

Mitochondrion

7 of 1640

0.89

0.71

0.0018

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31610802

(2019) Aminoacyl tRNA synthetases as potential drug targets of the Panthera pathogen Babesia.

4 of 17

2.64

2.58

1.63e-05

PMID:29579307

(2018) A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities.

3 of 11

2.7

1.58

0.0013

PMID:26109058

(2015) Nuclear respiratory factor 2 induces SIRT3 expression.

3 of 20

2.44

1.33

0.0035

PMID:22386318

(2012) Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression.

3 of 19

2.46

1.33

0.0035

PMID:37148543

(2023) Induction of endoplasmic reticulum stress is associated with the anti-tumor activity of monepantel across cancer types.

3 of 23

2.38

1.32

0.0036

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1857

Aminoacyl-tRNA biosynthesis

6 of 30

2.56

5.3

4.26e-11

CL:1863

aminoacyl-tRNA synthetase multienzyme complex

4 of 5

3.17

4.61

3.85e-09

CL:2589

Mitochondrial transcription, and Gamma DNA polymerase complex

4 of 11

2.82

4.03

3.24e-08

CL:1899

alanyl-tRNA aminoacylation, and threonyl-tRNA aminoacylation

2 of 5

2.87

1.49

0.0020

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa00970

Aminoacyl-tRNA biosynthesis

6 of 36

2.49

5.53

8.44e-12

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0017101

aminoacyl-tRNA synthetase multienzyme complex

4 of 13

2.75

3.59

2.06e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

5 of 18

2.71

5.07

2.27e-10

KW-0648

Protein biosynthesis

5 of 75

2.09

3.4

5.33e-08

KW-0820

tRNA-binding

3 of 10

2.74

2.95

3.52e-06

KW-0067

ATP-binding

5 of 770

1.08

0.84

0.0026

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01411

tRNA synthetases class II (A)

2 of 3

3.09

1.22

0.0062

PF09334

tRNA synthetases class I (M)

2 of 8

2.66

1.02

0.0139

PF03129

Anticodon binding domain

2 of 10

2.56

1.02

0.0139

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00991

A conserved domain of 46 amino acids, called WHEP-TRS has been shown PUBMED:1756734 to exist in a number of higher eukaryote aminoacyl-transfer RNA synthetases. This domain is present one to six times in the several enzymes. There are three copies in ...

2 of 6

2.79

1.22

0.0061

SM00863

Threonyl and Alanyl tRNA synthetase second additional domain

2 of 6

2.79

1.22

0.0061

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