RASAL2 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

RASAL2

RAS protein activator like 2. (1265 aa)

Predicted Functional Partners:

TC2N

0.706

RERG

0.630

CSDC2

0.586

ARHGAP5

0.585

ARHGAP35

0.565

RASA1

0.464

NF1

0.454

SWAP70

0.441

ARHGAP22

0.438

SLITRK2

0.437

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP22	RASA1	ENSAPLP00000028850	ENSAPLP00000005236	Rho GTPase activating protein 22.	RAS p21 protein activator 1.	0.442
ARHGAP22	RASAL2	ENSAPLP00000028850	ENSAPLP00000014460	Rho GTPase activating protein 22.	RAS protein activator like 2.	0.438
ARHGAP35	ARHGAP5	ENSAPLP00000002344	ENSAPLP00000015220	Rho GTPase activating protein 35.	Rho GTPase activating protein 5.	0.900
ARHGAP35	RASA1	ENSAPLP00000002344	ENSAPLP00000005236	Rho GTPase activating protein 35.	RAS p21 protein activator 1.	0.991
ARHGAP35	RASAL2	ENSAPLP00000002344	ENSAPLP00000014460	Rho GTPase activating protein 35.	RAS protein activator like 2.	0.565
ARHGAP5	ARHGAP35	ENSAPLP00000015220	ENSAPLP00000002344	Rho GTPase activating protein 5.	Rho GTPase activating protein 35.	0.900
ARHGAP5	RASA1	ENSAPLP00000015220	ENSAPLP00000005236	Rho GTPase activating protein 5.	RAS p21 protein activator 1.	0.877
ARHGAP5	RASAL2	ENSAPLP00000015220	ENSAPLP00000014460	Rho GTPase activating protein 5.	RAS protein activator like 2.	0.585
CSDC2	RASAL2	ENSAPLP00000004599	ENSAPLP00000014460	Cold shock domain containing C2.	RAS protein activator like 2.	0.586
NF1	RASA1	ENSAPLP00000014584	ENSAPLP00000005236	Neurofibromin 1.	RAS p21 protein activator 1.	0.721
NF1	RASAL2	ENSAPLP00000014584	ENSAPLP00000014460	Neurofibromin 1.	RAS protein activator like 2.	0.454
NF1	RERG	ENSAPLP00000014584	ENSAPLP00000013545	Neurofibromin 1.	RAS like estrogen regulated growth inhibitor.	0.402
RASA1	ARHGAP22	ENSAPLP00000005236	ENSAPLP00000028850	RAS p21 protein activator 1.	Rho GTPase activating protein 22.	0.442
RASA1	ARHGAP35	ENSAPLP00000005236	ENSAPLP00000002344	RAS p21 protein activator 1.	Rho GTPase activating protein 35.	0.991
RASA1	ARHGAP5	ENSAPLP00000005236	ENSAPLP00000015220	RAS p21 protein activator 1.	Rho GTPase activating protein 5.	0.877
RASA1	NF1	ENSAPLP00000005236	ENSAPLP00000014584	RAS p21 protein activator 1.	Neurofibromin 1.	0.721
RASA1	RASAL2	ENSAPLP00000005236	ENSAPLP00000014460	RAS p21 protein activator 1.	RAS protein activator like 2.	0.464
RASA1	SWAP70	ENSAPLP00000005236	ENSAPLP00000002560	RAS p21 protein activator 1.	Switching B cell complex subunit SWAP70.	0.439
RASAL2	ARHGAP22	ENSAPLP00000014460	ENSAPLP00000028850	RAS protein activator like 2.	Rho GTPase activating protein 22.	0.438
RASAL2	ARHGAP35	ENSAPLP00000014460	ENSAPLP00000002344	RAS protein activator like 2.	Rho GTPase activating protein 35.	0.565

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.888

expected number of edges:

11

PPI enrichment p-value:

1.06e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032511

Late endosome to vacuole transport via multivesicular body sorting pathway

3 of 13

2.54

1.61

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:30572

Mixed, incl. Late endosome to vacuole transport via multivesicular body sorting pathway, and HCN channels

9 of 30

2.66

9.23

1.61e-19

CL:30574

Mixed, incl. Late endosome to vacuole transport via multivesicular body sorting pathway, and Polypeptide N-acetylgalactosaminyltransferase activity

8 of 18

2.83

9.07

2.19e-18

CL:30577

Mixed, incl. Synaptonemal complex protein 2-like, and Rab-GTPase-TBC domain

5 of 6

3.1

5.88

1.49e-11

CL:30595

Vps55/LEPROT, and Uncharacterised protein family UPF0220

3 of 5

2.96

2.81

7.42e-06

CL:19564

Dystrophin-associated glycoprotein complex, and EF-hand

2 of 14

2.33

0.87

0.0251

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016012

Sarcoglycan complex

2 of 5

2.78

1.04

0.0129

GOCC:0005927

Muscle tendon junction

2 of 6

2.7

1.04

0.0129

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05255

Uncharacterised protein family (UPF0220)

2 of 2

3.18

1.3

0.0046

PF04790

Sarcoglycan complex subunit protein

2 of 5

2.78

1.15

0.0081

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007919

Uncharacterised protein family UPF0220

2 of 2

3.18

1.02

0.0145

IPR039972

Sarcoglycan gamma/delta/zeta

2 of 4

2.88

0.97

0.0181

IPR006875

Sarcoglycan complex subunit protein

2 of 5

2.78

0.96

0.0181

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