ZRANB3 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

ZRANB3

Zinc finger RANBP2-type containing 3. (1100 aa)

Predicted Functional Partners:

PRIMPOL

0.857

PCNA

0.847

FANCM

0.809

FBH1

0.785

SMARCAL1

0.783

U3I2H1_ANAPP

0.740

ERCC8

0.729

RAD18

0.724

EXO1

0.711

RAD54L

0.705

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERCC8	PRIMPOL	ENSAPLP00000009429	ENSAPLP00000021460	ERCC excision repair 8, CSA ubiquitin ligase complex subunit.	Primase and DNA directed polymerase.	0.610
ERCC8	SMARCAL1	ENSAPLP00000009429	ENSAPLP00000028785	ERCC excision repair 8, CSA ubiquitin ligase complex subunit.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.448
ERCC8	ZRANB3	ENSAPLP00000009429	ENSAPLP00000014680	ERCC excision repair 8, CSA ubiquitin ligase complex subunit.	Zinc finger RANBP2-type containing 3.	0.729
EXO1	FANCM	ENSAPLP00000014890	ENSAPLP00000027475	Exonuclease 1.	FA complementation group M.	0.904
EXO1	FBH1	ENSAPLP00000014890	ENSAPLP00000009506	Exonuclease 1.	F-box DNA helicase 1.	0.715
EXO1	PCNA	ENSAPLP00000014890	ENSAPLP00000028238	Exonuclease 1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.963
EXO1	PRIMPOL	ENSAPLP00000014890	ENSAPLP00000021460	Exonuclease 1.	Primase and DNA directed polymerase.	0.656
EXO1	RAD18	ENSAPLP00000014890	ENSAPLP00000002608	Exonuclease 1.	RAD18 E3 ubiquitin protein ligase.	0.674
EXO1	RAD54L	ENSAPLP00000014890	ENSAPLP00000006014	Exonuclease 1.	RAD54 like.	0.844
EXO1	SMARCAL1	ENSAPLP00000014890	ENSAPLP00000028785	Exonuclease 1.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.809
EXO1	U3I2H1_ANAPP	ENSAPLP00000014890	ENSAPLP00000001441	Exonuclease 1.	Uncharacterized protein.	0.998
EXO1	ZRANB3	ENSAPLP00000014890	ENSAPLP00000014680	Exonuclease 1.	Zinc finger RANBP2-type containing 3.	0.711
FANCM	EXO1	ENSAPLP00000027475	ENSAPLP00000014890	FA complementation group M.	Exonuclease 1.	0.904
FANCM	FBH1	ENSAPLP00000027475	ENSAPLP00000009506	FA complementation group M.	F-box DNA helicase 1.	0.988
FANCM	PCNA	ENSAPLP00000027475	ENSAPLP00000028238	FA complementation group M.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.979
FANCM	PRIMPOL	ENSAPLP00000027475	ENSAPLP00000021460	FA complementation group M.	Primase and DNA directed polymerase.	0.620
FANCM	RAD18	ENSAPLP00000027475	ENSAPLP00000002608	FA complementation group M.	RAD18 E3 ubiquitin protein ligase.	0.926
FANCM	RAD54L	ENSAPLP00000027475	ENSAPLP00000006014	FA complementation group M.	RAD54 like.	0.871
FANCM	SMARCAL1	ENSAPLP00000027475	ENSAPLP00000028785	FA complementation group M.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.871
FANCM	U3I2H1_ANAPP	ENSAPLP00000027475	ENSAPLP00000001441	FA complementation group M.	Uncharacterized protein.	0.998

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.911

expected number of edges:

11

PPI enrichment p-value:

2.24e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007035

Vacuolar acidification

4 of 11

2.23

2.14

7.25e-05

GO:0070072

Vacuolar proton-transporting V-type ATPase complex assembly

2 of 5

2.27

0.88

0.0243

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046961

Proton-transporting ATPase activity, rotational mechanism

4 of 15

2.1

2.0

0.00011

GO:0015075

Ion transmembrane transporter activity

5 of 184

1.1

0.79

0.0061

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016471

Vacuolar proton-transporting V-type ATPase complex

4 of 14

2.13

2.23

3.64e-05

GO:0000220

Vacuolar proton-transporting V-type ATPase, V0 domain

3 of 6

2.37

1.94

0.00022

GO:0000329

Fungal-type vacuole membrane

5 of 120

1.29

1.17

0.00057

GO:0098588

Bounding membrane of organelle

6 of 450

0.79

0.54

0.0104

GO:0031090

Organelle membrane

9 of 997

0.63

0.49

0.0018

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:26791325

(2016) Predicting chemotherapeutic drug combinations through gene network profiling.

5 of 27

1.94

2.06

5.26e-05

PMID:36422040

(2022) Subunit C of V-ATPase-VmaC Is Required for Hyphal Growth and Conidiation in A. fumigatus by Affecting Vacuolar Calcium Homeostasis and Cell Wall Integration.

4 of 15

2.1

1.75

0.00038

PMID:24708151

(2014) A functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system.

4 of 18

2.02

1.68

0.00047

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2344

Vacuolar proton-transporting V-type ATPase complex

4 of 13

2.16

2.29

2.95e-05

CL:7052

Mixed, incl. Vacuolar proton-transporting V-type ATPase complex assembly, and Exopolyphosphatase activity

4 of 19

1.99

2.08

5.45e-05

CL:7055

Mixed, incl. Glycine transport, and Cactus-binding C-terminus of cactin protein

3 of 6

2.37

2.0

0.00017

CL:2348

Insulin receptor recycling

3 of 8

2.24

1.91

0.00022

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

spo04145

Phagosome

4 of 33

1.75

1.85

7.82e-05

spo00190

Oxidative phosphorylation

4 of 65

1.46

1.34

0.00049

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

SPO-917977

Transferrin endocytosis and recycling

4 of 13

2.16

2.38

1.85e-05

SPO-77387

Insulin receptor recycling

4 of 13

2.16

2.38

1.85e-05

SPO-1222556

ROS and RNS production in phagocytes

4 of 14

2.13

2.37

1.85e-05

SPO-9639288

Amino acids regulate mTORC1

4 of 20

1.97

2.27

1.85e-05

SPO-168249

Innate Immune System

5 of 191

1.09

0.89

0.0017

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016471

Vacuolar proton-transporting V-type ATPase complex

4 of 14

2.13

2.26

3.15e-05

GOCC:0000220

Vacuolar proton-transporting V-type ATPase, V0 domain

3 of 6

2.37

2.04

0.00014

GOCC:0005774

Vacuolar membrane

5 of 133

1.24

1.12

0.00060

GOCC:0031090

Organelle membrane

9 of 616

0.83

0.77

7.33e-05

GOCC:0098588

Bounding membrane of organelle

6 of 313

0.95

0.77

0.0016

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0375

Hydrogen ion transport

4 of 33

1.75

1.68

0.00023

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