STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor bound protein 2.
   
0.986
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 0.949
GAB1
GRB2 associated binding protein 1.
    
 0.934
RUNX1
Runt-related transcription factor.
   
 
 0.926
SHC1
SHC adaptor protein 1.
   
 0.913
FRS2
Fibroblast growth factor receptor substrate 2.
    
 0.879
PDGFRB
Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
   
 0.837
PSME3
Proteasome activator subunit 3.
   
    0.789
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2.
    
 0.785
FRS3
Fibroblast growth factor receptor substrate 3.
    
 0.751
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.