TMEM230 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Score

TMEM230

Transmembrane protein 230. (120 aa)

Predicted Functional Partners:

TMEM175

0.747

ENSAPLP00000025521

0.715

SCAMP5

0.559

ENSAPLP00000022950

0.559

SCAMP4

0.559

PNKD

0.552

SLC35D3

0.526

GPR34

0.493

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAPLP00000022950	TMEM230	ENSAPLP00000022950	ENSAPLP00000015943	Secretory carrier-associated membrane protein.	Transmembrane protein 230.	0.559
ENSAPLP00000025521	TMEM175	ENSAPLP00000025521	ENSAPLP00000027752	Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.	Transmembrane protein 175.	0.586
ENSAPLP00000025521	TMEM230	ENSAPLP00000025521	ENSAPLP00000015943	Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.	Transmembrane protein 230.	0.715
GPR34	PNKD	ENSAPLP00000001523	ENSAPLP00000021650	G protein-coupled receptor 34; Belongs to the G-protein coupled receptor 1 family.	PNKD metallo-beta-lactamase domain containing.	0.434
GPR34	TMEM230	ENSAPLP00000001523	ENSAPLP00000015943	G protein-coupled receptor 34; Belongs to the G-protein coupled receptor 1 family.	Transmembrane protein 230.	0.493
PNKD	GPR34	ENSAPLP00000021650	ENSAPLP00000001523	PNKD metallo-beta-lactamase domain containing.	G protein-coupled receptor 34; Belongs to the G-protein coupled receptor 1 family.	0.434
PNKD	SLC35D3	ENSAPLP00000021650	ENSAPLP00000026778	PNKD metallo-beta-lactamase domain containing.	Solute carrier family 35 member D3.	0.547
PNKD	TMEM230	ENSAPLP00000021650	ENSAPLP00000015943	PNKD metallo-beta-lactamase domain containing.	Transmembrane protein 230.	0.552
SCAMP4	TMEM230	ENSAPLP00000030915	ENSAPLP00000015943	Secretory carrier-associated membrane protein.	Transmembrane protein 230.	0.559
SCAMP5	TMEM230	ENSAPLP00000014749	ENSAPLP00000015943	Secretory carrier-associated membrane protein.	Transmembrane protein 230.	0.559
SLC35D3	PNKD	ENSAPLP00000026778	ENSAPLP00000021650	Solute carrier family 35 member D3.	PNKD metallo-beta-lactamase domain containing.	0.547
SLC35D3	TMEM230	ENSAPLP00000026778	ENSAPLP00000015943	Solute carrier family 35 member D3.	Transmembrane protein 230.	0.526
TMEM175	ENSAPLP00000025521	ENSAPLP00000027752	ENSAPLP00000025521	Transmembrane protein 175.	Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.	0.586
TMEM175	TMEM230	ENSAPLP00000027752	ENSAPLP00000015943	Transmembrane protein 175.	Transmembrane protein 230.	0.747
TMEM230	ENSAPLP00000022950	ENSAPLP00000015943	ENSAPLP00000022950	Transmembrane protein 230.	Secretory carrier-associated membrane protein.	0.559
TMEM230	ENSAPLP00000025521	ENSAPLP00000015943	ENSAPLP00000025521	Transmembrane protein 230.	Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.	0.715
TMEM230	GPR34	ENSAPLP00000015943	ENSAPLP00000001523	Transmembrane protein 230.	G protein-coupled receptor 34; Belongs to the G-protein coupled receptor 1 family.	0.493
TMEM230	PNKD	ENSAPLP00000015943	ENSAPLP00000021650	Transmembrane protein 230.	PNKD metallo-beta-lactamase domain containing.	0.552
TMEM230	SCAMP4	ENSAPLP00000015943	ENSAPLP00000030915	Transmembrane protein 230.	Secretory carrier-associated membrane protein.	0.559
TMEM230	SCAMP5	ENSAPLP00000015943	ENSAPLP00000014749	Transmembrane protein 230.	Secretory carrier-associated membrane protein.	0.559

page 1 of 2

Network Stats

number of nodes:

7

number of edges:

12

average node degree:

3.43

avg. local clustering coefficient:

0.914

expected number of edges:

6

PPI enrichment p-value:

0.0285

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031016

Pancreas development

3 of 58

2.29

1.64

0.0029

GO:0031018

Endocrine pancreas development

2 of 28

2.43

0.89

0.0471

GO:0048513

Animal organ development

6 of 2515

0.96

0.71

0.0073

GO:0048731

System development

6 of 3299

0.84

0.54

0.0246

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

5 of 1344

1.15

0.82

0.0109

GO:1990837

Sequence-specific double-stranded DNA binding

5 of 1430

1.12

0.8

0.0109

GO:0000977

RNA polymerase II transcription regulatory region sequence-specific DNA binding

4 of 1284

1.07

0.6

0.0460

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:32099

Mixed, incl. Neuron fate specification, and Regulation of beta-cell development

3 of 27

2.63

2.43

0.00020

CL:32102

Mixed, incl. Pancreatic A cell differentiation, and Neuronal helix-loop-helix transcription factor

2 of 10

2.88

1.68

0.0032

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-186712

Regulation of beta-cell development

3 of 29

2.6

2.66

8.26e-05

MAP-210745

Regulation of gene expression in beta cells

2 of 13

2.77

1.54

0.0050

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02257

RFX DNA-binding domain

2 of 8

2.98

1.51

0.0059

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039779

RFX-like DNA-binding protein

2 of 9

2.93

1.12

0.0224

IPR003150

DNA-binding RFX-type winged-helix domain

2 of 10

2.88

1.12

0.0224

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