PEX7 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

PEX7

Peroxisomal biogenesis factor 7. (327 aa)

Predicted Functional Partners:

PEX5L

0.994

PEX5

0.993

ACAA1

0.986

PEX14

0.965

PEX13

0.962

AGPS

0.944

ENSAPLP00000020216

0.935

PEX10

0.921

FAM185A

0.900

HADHB

0.840

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAA1	AGPS	ENSAPLP00000005831	ENSAPLP00000025478	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Alkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.	0.532
ACAA1	ENSAPLP00000020216	ENSAPLP00000005831	ENSAPLP00000020216	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.712
ACAA1	FAM185A	ENSAPLP00000005831	ENSAPLP00000028756	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Family with sequence similarity 185 member A.	0.728
ACAA1	HADHB	ENSAPLP00000005831	ENSAPLP00000002942	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family.	0.918
ACAA1	PEX10	ENSAPLP00000005831	ENSAPLP00000009116	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Peroxisomal biogenesis factor 10.	0.812
ACAA1	PEX13	ENSAPLP00000005831	ENSAPLP00000005837	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Peroxisomal biogenesis factor 13.	0.797
ACAA1	PEX14	ENSAPLP00000005831	ENSAPLP00000005813	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Peroxisomal biogenesis factor 14.	0.785
ACAA1	PEX5	ENSAPLP00000005831	ENSAPLP00000007675	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Peroxisomal biogenesis factor 5.	0.712
ACAA1	PEX5L	ENSAPLP00000005831	ENSAPLP00000010931	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Peroxisomal biogenesis factor 5 like.	0.712
ACAA1	PEX7	ENSAPLP00000005831	ENSAPLP00000016136	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Peroxisomal biogenesis factor 7.	0.986
AGPS	ACAA1	ENSAPLP00000025478	ENSAPLP00000005831	Alkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.532
AGPS	ENSAPLP00000020216	ENSAPLP00000025478	ENSAPLP00000020216	Alkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.	Uncharacterized protein.	0.683
AGPS	FAM185A	ENSAPLP00000025478	ENSAPLP00000028756	Alkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.	Family with sequence similarity 185 member A.	0.653
AGPS	PEX10	ENSAPLP00000025478	ENSAPLP00000009116	Alkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.	Peroxisomal biogenesis factor 10.	0.832
AGPS	PEX13	ENSAPLP00000025478	ENSAPLP00000005837	Alkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.	Peroxisomal biogenesis factor 13.	0.766
AGPS	PEX14	ENSAPLP00000025478	ENSAPLP00000005813	Alkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.	Peroxisomal biogenesis factor 14.	0.778
AGPS	PEX5	ENSAPLP00000025478	ENSAPLP00000007675	Alkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.	Peroxisomal biogenesis factor 5.	0.683
AGPS	PEX5L	ENSAPLP00000025478	ENSAPLP00000010931	Alkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.	Peroxisomal biogenesis factor 5 like.	0.716
AGPS	PEX7	ENSAPLP00000025478	ENSAPLP00000016136	Alkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.	Peroxisomal biogenesis factor 7.	0.944
ENSAPLP00000020216	ACAA1	ENSAPLP00000020216	ENSAPLP00000005831	Uncharacterized protein.	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.712

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007186

G protein-coupled receptor signaling pathway

9 of 1311

1.1

1.21

1.12e-05

GO:0007165

Signal transduction

11 of 4180

0.68

0.59

0.00016

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030159

Signaling receptor complex adaptor activity

5 of 39

2.37

3.69

5.31e-08

GO:0031681

G-protein beta-subunit binding

3 of 24

2.36

1.95

0.00021

GO:0003924

GTPase activity

6 of 338

1.51

1.86

1.00e-05

GO:0051020

GTPase binding

4 of 279

1.42

1.07

0.0031

GO:0019899

Enzyme binding

6 of 1712

0.81

0.48

0.0297

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

7 of 36

2.55

6.58

5.97e-14

GO:0005886

Plasma membrane

10 of 4723

0.59

0.49

0.00055

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:32466321

(2020) Oviductal Extracellular Vesicles Improve Post-Thaw Sperm Function in Red Wolves and Cheetahs.

3 of 27

2.31

0.92

0.0201

PMID:19375447

(2009) Naturally occurring animal models with outer retina phenotypes.

3 of 24

2.36

0.92

0.0201

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18961

G beta:gamma signalling through BTK, and Phosducin

6 of 11

3.0

6.74

2.72e-13

CL:18951

G alpha (i) signalling events, and Inward rectifier potassium channel activity

8 of 131

2.05

4.9

1.49e-12

CL:18953

Mixed, incl. GABA B receptor activation, and Regulator of G protein signalling domain

7 of 98

2.12

4.66

2.87e-11

CL:18963

G beta:gamma signalling through BTK, and Serotonin receptors

4 of 6

3.09

4.53

4.99e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa04062

Chemokine signaling pathway

11 of 159

2.1

7.47

3.57e-21

cfa04727

GABAergic synapse

8 of 73

2.3

6.83

5.06e-16

cfa05032

Morphine addiction

8 of 77

2.28

6.75

5.41e-16

cfa04713

Circadian entrainment

8 of 85

2.24

6.52

1.00e-15

cfa04726

Serotonergic synapse

8 of 91

2.21

6.36

1.49e-15

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-8964315

G beta:gamma signalling through BTK

8 of 17

2.94

9.59

4.14e-19

CFA-8964616

G beta:gamma signalling through CDC42

8 of 19

2.89

9.51

4.24e-19

CFA-418217

G beta:gamma signalling through PLC beta

8 of 19

2.89

9.51

4.24e-19

CFA-500657

Presynaptic function of Kainate receptors

8 of 20

2.87

9.48

4.24e-19

CFA-400042

Adrenaline,noradrenaline inhibits insulin secretion

8 of 20

2.87

9.48

4.24e-19

(more ...)

WikiPathways

pathway

description

count in network

strength

signal

false discovery rate

WP1165

G protein signaling pathways

5 of 75

2.09

3.65

1.20e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

6 of 25

2.64

5.76

6.55e-12

GOCC:0031680

G-protein beta/gamma-subunit complex

2 of 5

2.87

1.65

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

5 of 244

1.58

1.75

4.89e-05

KW-0449

Lipoprotein

3 of 127

1.64

1.0

0.0085

KW-0807

Transducer

5 of 1006

0.96

0.61

0.0153

KW-0677

Repeat

5 of 1186

0.89

0.53

0.0249

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020472

G-protein beta WD-40 repeat

2 of 2

3.26

1.64

0.0011

IPR019775

WD40 repeat, conserved site

2 of 3

3.09

1.64

0.0011

IPR016346

Guanine nucleotide-binding protein, beta subunit

2 of 2

3.26

1.64

0.0011

IPR001632

G-protein, beta subunit

2 of 2

3.26

1.64

0.0011

IPR036322

WD40-repeat-containing domain superfamily

2 of 4

2.96

1.63

0.0011

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00224

G protein gamma subunit-like motifs

3 of 17

2.51

2.12

0.00011

SM00320

WD40 repeats

5 of 269

1.53

1.6

0.00011

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