ENSAPLP00000016792 protein (Anas platyrhynchos)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

ENSAPLP00000016792

Protein kinase domain-containing protein. (206 aa)

Predicted Functional Partners:

PDPK1

0.958

APPL1

0.754

APPL2

0.754

FOXO1

0.739

FOXO3

0.731

TSC1

0.720

RICTOR

0.720

MDM2

0.714

ENSAPLP00000030500

0.699

MTOR

0.688

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APPL1	APPL2	ENSAPLP00000004064	ENSAPLP00000014997	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.966
APPL1	ENSAPLP00000016792	ENSAPLP00000004064	ENSAPLP00000016792	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Protein kinase domain-containing protein.	0.754
APPL1	ENSAPLP00000030500	ENSAPLP00000004064	ENSAPLP00000030500	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Protein kinase domain-containing protein.	0.754
APPL2	APPL1	ENSAPLP00000014997	ENSAPLP00000004064	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.966
APPL2	ENSAPLP00000016792	ENSAPLP00000014997	ENSAPLP00000016792	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Protein kinase domain-containing protein.	0.754
APPL2	ENSAPLP00000030500	ENSAPLP00000014997	ENSAPLP00000030500	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Protein kinase domain-containing protein.	0.754
ENSAPLP00000016792	APPL1	ENSAPLP00000016792	ENSAPLP00000004064	Protein kinase domain-containing protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.754
ENSAPLP00000016792	APPL2	ENSAPLP00000016792	ENSAPLP00000014997	Protein kinase domain-containing protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.754
ENSAPLP00000016792	ENSAPLP00000030500	ENSAPLP00000016792	ENSAPLP00000030500	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.699
ENSAPLP00000016792	FOXO1	ENSAPLP00000016792	ENSAPLP00000003516	Protein kinase domain-containing protein.	Forkhead box O1.	0.739
ENSAPLP00000016792	FOXO3	ENSAPLP00000016792	ENSAPLP00000011053	Protein kinase domain-containing protein.	Fork-head domain-containing protein.	0.731
ENSAPLP00000016792	MDM2	ENSAPLP00000016792	ENSAPLP00000010914	Protein kinase domain-containing protein.	Uncharacterized protein.	0.714
ENSAPLP00000016792	MTOR	ENSAPLP00000016792	ENSAPLP00000007032	Protein kinase domain-containing protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.688
ENSAPLP00000016792	PDPK1	ENSAPLP00000016792	ENSAPLP00000015587	Protein kinase domain-containing protein.	3-phosphoinositide dependent protein kinase 1.	0.958
ENSAPLP00000016792	RICTOR	ENSAPLP00000016792	ENSAPLP00000027785	Protein kinase domain-containing protein.	RPTOR independent companion of MTOR complex 2.	0.720
ENSAPLP00000016792	TSC1	ENSAPLP00000016792	ENSAPLP00000001959	Protein kinase domain-containing protein.	TSC complex subunit 1.	0.720
ENSAPLP00000030500	APPL1	ENSAPLP00000030500	ENSAPLP00000004064	Protein kinase domain-containing protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.754
ENSAPLP00000030500	APPL2	ENSAPLP00000030500	ENSAPLP00000014997	Protein kinase domain-containing protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.754
ENSAPLP00000030500	ENSAPLP00000016792	ENSAPLP00000030500	ENSAPLP00000016792	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.699
ENSAPLP00000030500	FOXO1	ENSAPLP00000030500	ENSAPLP00000003516	Protein kinase domain-containing protein.	Forkhead box O1.	0.739

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.788

expected number of edges:

11

PPI enrichment p-value:

2.85e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042558

Pteridine-containing compound metabolic process

3 of 10

1.68

1.2

0.0031

GO:0006431

methionyl-tRNA aminoacylation

2 of 2

2.21

1.09

0.0092

GO:0006520

Cellular amino acid metabolic process

6 of 86

1.05

0.94

0.00052

GO:0009086

Methionine biosynthetic process

2 of 5

1.81

0.89

0.0185

GO:0016070

RNA metabolic process

6 of 98

0.99

0.84

0.00098

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004825

methionine-tRNA ligase activity

2 of 2

2.21

0.82

0.0309

GO:0016741

Transferase activity, transferring one-carbon groups

4 of 34

1.28

0.71

0.0235

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

2 of 4

1.91

0.7

0.0473

GO:0016646

Oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

2 of 6

1.73

0.68

0.0474

GO:0140101

Catalytic activity, acting on a tRNA

4 of 43

1.17

0.65

0.0276

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

7 of 178

0.8

0.63

0.0021

GO:0005622

Intracellular anatomical structure

11 of 747

0.37

0.31

0.0031

GO:0005737

Cytoplasm

10 of 672

0.38

0.3

0.0120

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:362

16S rRNA methyltransferase RsmB/F, and Formyl transferase

4 of 5

2.11

2.22

3.83e-05

CL:291

tRNA aminoacylation

3 of 13

1.57

1.03

0.0061

CL:79

Translation, and RNA biosynthetic process

7 of 147

0.88

0.71

0.0015

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cgo00670

One carbon pool by folate

5 of 9

1.95

2.85

5.07e-07

cgo00450

Selenocompound metabolism

3 of 6

1.91

1.59

0.00060

cgo00970

Aminoacyl-tRNA biosynthesis

4 of 27

1.38

1.24

0.00063

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0648

Protein biosynthesis

5 of 41

1.29

1.17

0.00060

KW-0030

Aminoacyl-tRNA synthetase

3 of 23

1.32

0.67

0.0333

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