STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSAPLP00000017981Receptor protein-tyrosine kinase. (513 aa)    
Predicted Functional Partners:
EGF
Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
   
 0.973
PLXNB1
Plexin B1.
    
 0.943
GRB2
Growth factor receptor bound protein 2.
    
 0.913
NRG1
Neuregulin 1.
    
 0.880
CBL
Cbl proto-oncogene.
    
 0.846
SHC1
SHC adaptor protein 1.
    
 0.829
EREG
Epiregulin.
    
 0.810
CBLB
Cbl proto-oncogene B.
    
 0.800
MET
MET proto-oncogene, receptor tyrosine kinase.
   
0.769
ESR1
Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
    
 0.763
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.