ENSAPLP00000018529 protein (Anas platyrhynchos)

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second shell of interactors

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Known Interactions

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Predicted Interactions

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protein homology

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Score

ENSAPLP00000018529

Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (600 aa)

Predicted Functional Partners:

SDC1

0.669

NOTUM

0.640

UNC5D

0.579

EXT1

0.570

SHH

0.514

DHH

0.514

IHH

0.514

UNC5C

0.511

SLC10A1

0.488

SDC3

0.488

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHH	ENSAPLP00000018529	ENSAPLP00000024838	ENSAPLP00000018529	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.514
DHH	NOTUM	ENSAPLP00000024838	ENSAPLP00000026307	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Notum, palmitoleoyl-protein carboxylesterase.	0.535
ENSAPLP00000018529	DHH	ENSAPLP00000018529	ENSAPLP00000024838	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.514
ENSAPLP00000018529	EXT1	ENSAPLP00000018529	ENSAPLP00000009664	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family.	0.570
ENSAPLP00000018529	IHH	ENSAPLP00000018529	ENSAPLP00000027501	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.514
ENSAPLP00000018529	NOTUM	ENSAPLP00000018529	ENSAPLP00000026307	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Notum, palmitoleoyl-protein carboxylesterase.	0.640
ENSAPLP00000018529	SDC1	ENSAPLP00000018529	ENSAPLP00000010205	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.669
ENSAPLP00000018529	SDC3	ENSAPLP00000018529	ENSAPLP00000025106	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.488
ENSAPLP00000018529	SHH	ENSAPLP00000018529	ENSAPLP00000006846	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Sonic hedgehog signaling molecule.	0.514
ENSAPLP00000018529	SLC10A1	ENSAPLP00000018529	ENSAPLP00000014650	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Solute carrier family 10 member 1.	0.488
ENSAPLP00000018529	UNC5C	ENSAPLP00000018529	ENSAPLP00000021173	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Unc-5 netrin receptor C.	0.511
ENSAPLP00000018529	UNC5D	ENSAPLP00000018529	ENSAPLP00000020277	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Unc-5 netrin receptor D.	0.579
EXT1	ENSAPLP00000018529	ENSAPLP00000009664	ENSAPLP00000018529	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family.	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.570
EXT1	SDC1	ENSAPLP00000009664	ENSAPLP00000010205	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.596
EXT1	SDC3	ENSAPLP00000009664	ENSAPLP00000025106	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.503
IHH	ENSAPLP00000018529	ENSAPLP00000027501	ENSAPLP00000018529	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.514
IHH	NOTUM	ENSAPLP00000027501	ENSAPLP00000026307	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Notum, palmitoleoyl-protein carboxylesterase.	0.535
NOTUM	DHH	ENSAPLP00000026307	ENSAPLP00000024838	Notum, palmitoleoyl-protein carboxylesterase.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.535
NOTUM	ENSAPLP00000018529	ENSAPLP00000026307	ENSAPLP00000018529	Notum, palmitoleoyl-protein carboxylesterase.	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.640
NOTUM	IHH	ENSAPLP00000026307	ENSAPLP00000027501	Notum, palmitoleoyl-protein carboxylesterase.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.535

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Network Stats

number of nodes:

7

number of edges:

12

average node degree:

3.43

avg. local clustering coefficient:

0.833

expected number of edges:

6

PPI enrichment p-value:

0.0205

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009279

Cell outer membrane

10 of 227

1.42

2.61

4.77e-12

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1434

TonB-dependent outer membrane protein SusC/RagA, conserved site, and SusD-like, N-terminal

9 of 97

1.74

3.78

4.29e-12

CL:1603

Mixed, incl. Secretin/TonB, short N-terminal domain, and Protein FecR, C-terminal

4 of 7

2.53

3.46

2.59e-07

CL:1442

SusD family, and TonB-dependent outer membrane protein SusC/RagA, conserved site

4 of 12

2.3

3.02

1.14e-06

CL:1438

TonB-dependent outer membrane protein SusC/RagA, conserved site, and SusD family

5 of 36

1.92

2.8

5.48e-07

CL:1454

Starch-binding associating with outer membrane, and TonB-dependent outer membrane protein SusC/RagA, conserved site

2 of 6

2.3

1.18

0.0065

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009279

Cell outer membrane

10 of 192

1.49

2.91

2.22e-12

GOCC:0071944

Cell periphery

11 of 732

0.95

1.16

2.08e-09

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF14322

Starch-binding associating with outer membrane

9 of 47

2.06

5.64

5.36e-15

PF07980

SusD family

9 of 54

1.99

5.36

8.36e-15

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033985

SusD-like, N-terminal

9 of 49

2.04

5.43

1.81e-14

IPR012944

RagB/SusD domain

9 of 53

2.0

5.3

1.81e-14

IPR011990

Tetratricopeptide-like helical domain superfamily

9 of 148

1.56

2.95

6.98e-11

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