PDX1 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PDX1

Homeobox domain-containing protein. (264 aa)

Predicted Functional Partners:

INS

0.654

SPOPL

0.594

SPOP

0.594

PAX6

0.508

PTF1A

0.498

PAX4

0.470

HNF1A

0.460

IRS4

0.453

IRS2

0.453

FOXA1

0.444

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FOXA1	PDX1	ENSAPLP00000020851	ENSAPLP00000019619	Forkhead box A1.	Homeobox domain-containing protein.	0.444
HNF1A	INS	ENSAPLP00000002032	ENSAPLP00000012854	Homeobox domain-containing protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.403
HNF1A	PAX4	ENSAPLP00000002032	ENSAPLP00000030875	Homeobox domain-containing protein.	Paired box 4.	0.492
HNF1A	PDX1	ENSAPLP00000002032	ENSAPLP00000019619	Homeobox domain-containing protein.	Homeobox domain-containing protein.	0.460
HNF1A	PTF1A	ENSAPLP00000002032	ENSAPLP00000021312	Homeobox domain-containing protein.	Pancreas associated transcription factor 1a.	0.457
INS	HNF1A	ENSAPLP00000012854	ENSAPLP00000002032	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Homeobox domain-containing protein.	0.403
INS	IRS2	ENSAPLP00000012854	ENSAPLP00000027984	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin receptor substrate 2.	0.587
INS	IRS4	ENSAPLP00000012854	ENSAPLP00000000739	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin receptor substrate 4.	0.971
INS	PAX4	ENSAPLP00000012854	ENSAPLP00000030875	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Paired box 4.	0.527
INS	PAX6	ENSAPLP00000012854	ENSAPLP00000004507	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Paired box 6.	0.735
INS	PDX1	ENSAPLP00000012854	ENSAPLP00000019619	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Homeobox domain-containing protein.	0.654
INS	PTF1A	ENSAPLP00000012854	ENSAPLP00000021312	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Pancreas associated transcription factor 1a.	0.620
IRS2	INS	ENSAPLP00000027984	ENSAPLP00000012854	Insulin receptor substrate 2.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.587
IRS2	PDX1	ENSAPLP00000027984	ENSAPLP00000019619	Insulin receptor substrate 2.	Homeobox domain-containing protein.	0.453
IRS4	INS	ENSAPLP00000000739	ENSAPLP00000012854	Insulin receptor substrate 4.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.971
IRS4	PDX1	ENSAPLP00000000739	ENSAPLP00000019619	Insulin receptor substrate 4.	Homeobox domain-containing protein.	0.453
PAX4	HNF1A	ENSAPLP00000030875	ENSAPLP00000002032	Paired box 4.	Homeobox domain-containing protein.	0.492
PAX4	INS	ENSAPLP00000030875	ENSAPLP00000012854	Paired box 4.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.527
PAX4	PDX1	ENSAPLP00000030875	ENSAPLP00000019619	Paired box 4.	Homeobox domain-containing protein.	0.470
PAX6	INS	ENSAPLP00000004507	ENSAPLP00000012854	Paired box 6.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.735