HPCAL4 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HPCAL4

Hippocalcin like 4. (191 aa)

Predicted Functional Partners:

CASK

0.691

PI4KB

0.678

TRIT1

0.674

NT5C1A

0.624

CCDC14

0.554

CAMK2D

0.534

GNAL

0.485

KCND3

0.480

KCND2

0.480

HEYL

0.468

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAMK2D	HPCAL4	ENSAPLP00000031887	ENSAPLP00000020562	Protein kinase domain-containing protein.	Hippocalcin like 4.	0.534
CASK	HPCAL4	ENSAPLP00000013836	ENSAPLP00000020562	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Hippocalcin like 4.	0.691
CCDC14	GNAL	ENSAPLP00000005870	ENSAPLP00000012442	Coiled-coil domain containing 14.	G protein subunit alpha L.	0.684
CCDC14	HPCAL4	ENSAPLP00000005870	ENSAPLP00000020562	Coiled-coil domain containing 14.	Hippocalcin like 4.	0.554
GNAL	CCDC14	ENSAPLP00000012442	ENSAPLP00000005870	G protein subunit alpha L.	Coiled-coil domain containing 14.	0.684
GNAL	HPCAL4	ENSAPLP00000012442	ENSAPLP00000020562	G protein subunit alpha L.	Hippocalcin like 4.	0.485
HEYL	HPCAL4	ENSAPLP00000030929	ENSAPLP00000020562	Hes related family bHLH transcription factor with YRPW motif like.	Hippocalcin like 4.	0.468
HEYL	NT5C1A	ENSAPLP00000030929	ENSAPLP00000010254	Hes related family bHLH transcription factor with YRPW motif like.	5'-nucleotidase, cytosolic IA.	0.429
HEYL	TRIT1	ENSAPLP00000030929	ENSAPLP00000011205	Hes related family bHLH transcription factor with YRPW motif like.	tRNA isopentenyltransferase 1; Belongs to the IPP transferase family.	0.467
HPCAL4	CAMK2D	ENSAPLP00000020562	ENSAPLP00000031887	Hippocalcin like 4.	Protein kinase domain-containing protein.	0.534
HPCAL4	CASK	ENSAPLP00000020562	ENSAPLP00000013836	Hippocalcin like 4.	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	0.691
HPCAL4	CCDC14	ENSAPLP00000020562	ENSAPLP00000005870	Hippocalcin like 4.	Coiled-coil domain containing 14.	0.554
HPCAL4	GNAL	ENSAPLP00000020562	ENSAPLP00000012442	Hippocalcin like 4.	G protein subunit alpha L.	0.485
HPCAL4	HEYL	ENSAPLP00000020562	ENSAPLP00000030929	Hippocalcin like 4.	Hes related family bHLH transcription factor with YRPW motif like.	0.468
HPCAL4	KCND2	ENSAPLP00000020562	ENSAPLP00000026964	Hippocalcin like 4.	BTB_2 domain-containing protein.	0.480
HPCAL4	KCND3	ENSAPLP00000020562	ENSAPLP00000013835	Hippocalcin like 4.	Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family.	0.480
HPCAL4	NT5C1A	ENSAPLP00000020562	ENSAPLP00000010254	Hippocalcin like 4.	5'-nucleotidase, cytosolic IA.	0.624
HPCAL4	PI4KB	ENSAPLP00000020562	ENSAPLP00000001897	Hippocalcin like 4.	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	0.678
HPCAL4	TRIT1	ENSAPLP00000020562	ENSAPLP00000011205	Hippocalcin like 4.	tRNA isopentenyltransferase 1; Belongs to the IPP transferase family.	0.674
KCND2	HPCAL4	ENSAPLP00000026964	ENSAPLP00000020562	BTB_2 domain-containing protein.	Hippocalcin like 4.	0.480

page 1 of 2

Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.211

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031072

Heat shock protein binding

3 of 73

1.83

0.82

0.0287

GO:0008276

Protein methyltransferase activity

3 of 78

1.81

0.82

0.0287

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035869

Ciliary transition zone

3 of 70

1.85

1.0

0.0126

GO:0036038

MKS complex

2 of 13

2.41

0.93

0.0226

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:29744

Lysine methyltransferase, and FAM86, N-terminal

4 of 12

2.74

3.52

4.42e-07

CL:16441

MKS complex, and Tectonic

3 of 5

3.0

2.93

6.48e-06

CL:29746

Lysine methyltransferase, and KOW (Kyprides, Ouzounis, Woese) motif.

3 of 6

2.92

2.87

8.09e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8876725

Protein methylation

6 of 22

2.66

6.01

4.49e-12

MAP-156902

Peptide chain elongation

2 of 2

3.22

1.6

0.0016

MAP-156842

Eukaryotic Translation Elongation

2 of 5

2.82

1.38

0.0038

MAP-5358493

Synthesis of diphthamide-EEF2

2 of 9

2.57

1.22

0.0068

MAP-5620912

Anchoring of the basal body to the plasma membrane

3 of 103

1.68

1.05

0.0081

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0036038

MKS complex

3 of 15

2.52

2.05

0.00020

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10294

Lysine methyltransferase

2 of 6

2.74

1.0

0.0177

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019410

Lysine methyltransferase

3 of 8

2.79

2.14

0.00016

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About