node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSAPLP00000026666 | FEN1 | ENSAPLP00000026666 | ENSAPLP00000001147 | DNA_pol_B domain-containing protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.729 |
ENSAPLP00000026666 | MAD2L2 | ENSAPLP00000026666 | ENSAPLP00000009219 | DNA_pol_B domain-containing protein. | Mitotic arrest deficient 2 like 2. | 0.995 |
ENSAPLP00000026666 | PCNA | ENSAPLP00000026666 | ENSAPLP00000028238 | DNA_pol_B domain-containing protein. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.922 |
ENSAPLP00000026666 | POLA1 | ENSAPLP00000026666 | ENSAPLP00000008748 | DNA_pol_B domain-containing protein. | DNA polymerase. | 0.575 |
ENSAPLP00000026666 | POLD2 | ENSAPLP00000026666 | ENSAPLP00000021348 | DNA_pol_B domain-containing protein. | DNA polymerase delta 2, accessory subunit. | 0.966 |
ENSAPLP00000026666 | POLD3 | ENSAPLP00000026666 | ENSAPLP00000004807 | DNA_pol_B domain-containing protein. | Uncharacterized protein. | 0.925 |
ENSAPLP00000026666 | POLE | ENSAPLP00000026666 | ENSAPLP00000009758 | DNA_pol_B domain-containing protein. | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.792 |
ENSAPLP00000026666 | PRIM2 | ENSAPLP00000026666 | ENSAPLP00000003262 | DNA_pol_B domain-containing protein. | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. | 0.934 |
ENSAPLP00000026666 | REV3L | ENSAPLP00000026666 | ENSAPLP00000022493 | DNA_pol_B domain-containing protein. | Uncharacterized protein. | 0.900 |
ENSAPLP00000026666 | U3I2H1_ANAPP | ENSAPLP00000026666 | ENSAPLP00000001441 | DNA_pol_B domain-containing protein. | Uncharacterized protein. | 0.780 |
FEN1 | ENSAPLP00000026666 | ENSAPLP00000001147 | ENSAPLP00000026666 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA_pol_B domain-containing protein. | 0.729 |
FEN1 | PCNA | ENSAPLP00000001147 | ENSAPLP00000028238 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.998 |
FEN1 | POLA1 | ENSAPLP00000001147 | ENSAPLP00000008748 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase. | 0.895 |
FEN1 | POLD2 | ENSAPLP00000001147 | ENSAPLP00000021348 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase delta 2, accessory subunit. | 0.972 |
FEN1 | POLD3 | ENSAPLP00000001147 | ENSAPLP00000004807 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.740 |
FEN1 | POLE | ENSAPLP00000001147 | ENSAPLP00000009758 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.894 |
FEN1 | PRIM2 | ENSAPLP00000001147 | ENSAPLP00000003262 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. | 0.805 |
FEN1 | REV3L | ENSAPLP00000001147 | ENSAPLP00000022493 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.729 |
FEN1 | U3I2H1_ANAPP | ENSAPLP00000001147 | ENSAPLP00000001441 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.999 |
MAD2L2 | ENSAPLP00000026666 | ENSAPLP00000009219 | ENSAPLP00000026666 | Mitotic arrest deficient 2 like 2. | DNA_pol_B domain-containing protein. | 0.995 |