TXNDC12 protein (Anas platyrhynchos) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

TXNDC12

Thioredoxin domain containing 12. (169 aa)

Predicted Functional Partners:

PRDX6

0.920

U3ICT4_ANAPP

0.907

ENSAPLP00000018289

0.907

ENSAPLP00000025237

0.907

U3IDF5_ANAPP

0.903

GSTO1

0.903

GSR

0.901

CHAC1

0.901

GPX7

0.901

MGST2

0.901

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHAC1	ENSAPLP00000018289	ENSAPLP00000001241	ENSAPLP00000018289	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein.	0.900
CHAC1	ENSAPLP00000025237	ENSAPLP00000001241	ENSAPLP00000025237	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein; Belongs to the GST superfamily.	0.901
CHAC1	GPX7	ENSAPLP00000001241	ENSAPLP00000006505	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.906
CHAC1	GSR	ENSAPLP00000001241	ENSAPLP00000000449	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.900
CHAC1	GSTO1	ENSAPLP00000001241	ENSAPLP00000028173	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Glutathione S-transferase omega 1.	0.931
CHAC1	MGST2	ENSAPLP00000001241	ENSAPLP00000006886	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Microsomal glutathione S-transferase 2.	0.908
CHAC1	PRDX6	ENSAPLP00000001241	ENSAPLP00000016332	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Peroxiredoxin 6.	0.900
CHAC1	TXNDC12	ENSAPLP00000001241	ENSAPLP00000021539	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Thioredoxin domain containing 12.	0.901
CHAC1	U3ICT4_ANAPP	ENSAPLP00000001241	ENSAPLP00000005056	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein.	0.900
CHAC1	U3IDF5_ANAPP	ENSAPLP00000001241	ENSAPLP00000005277	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Uncharacterized protein; Belongs to the GST superfamily.	0.900
ENSAPLP00000018289	CHAC1	ENSAPLP00000018289	ENSAPLP00000001241	Uncharacterized protein.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.900
ENSAPLP00000018289	ENSAPLP00000025237	ENSAPLP00000018289	ENSAPLP00000025237	Uncharacterized protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.953
ENSAPLP00000018289	GPX7	ENSAPLP00000018289	ENSAPLP00000006505	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.702
ENSAPLP00000018289	GSR	ENSAPLP00000018289	ENSAPLP00000000449	Uncharacterized protein.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.916
ENSAPLP00000018289	GSTO1	ENSAPLP00000018289	ENSAPLP00000028173	Uncharacterized protein.	Glutathione S-transferase omega 1.	0.968
ENSAPLP00000018289	MGST2	ENSAPLP00000018289	ENSAPLP00000006886	Uncharacterized protein.	Microsomal glutathione S-transferase 2.	0.910
ENSAPLP00000018289	PRDX6	ENSAPLP00000018289	ENSAPLP00000016332	Uncharacterized protein.	Peroxiredoxin 6.	0.958
ENSAPLP00000018289	TXNDC12	ENSAPLP00000018289	ENSAPLP00000021539	Uncharacterized protein.	Thioredoxin domain containing 12.	0.907
ENSAPLP00000018289	U3ICT4_ANAPP	ENSAPLP00000018289	ENSAPLP00000005056	Uncharacterized protein.	Uncharacterized protein.	0.901
ENSAPLP00000018289	U3IDF5_ANAPP	ENSAPLP00000018289	ENSAPLP00000005277	Uncharacterized protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.952

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.888

expected number of edges:

11

PPI enrichment p-value:

1.06e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032511

Late endosome to vacuole transport via multivesicular body sorting pathway

3 of 13

2.54

1.61

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:30572

Mixed, incl. Late endosome to vacuole transport via multivesicular body sorting pathway, and HCN channels

9 of 30

2.66

9.23

1.61e-19

CL:30574

Mixed, incl. Late endosome to vacuole transport via multivesicular body sorting pathway, and Polypeptide N-acetylgalactosaminyltransferase activity

8 of 18

2.83

9.07

2.19e-18

CL:30577

Mixed, incl. Synaptonemal complex protein 2-like, and Rab-GTPase-TBC domain

5 of 6

3.1

5.88

1.49e-11

CL:30595

Vps55/LEPROT, and Uncharacterised protein family UPF0220

3 of 5

2.96

2.81

7.42e-06

CL:19564

Dystrophin-associated glycoprotein complex, and EF-hand

2 of 14

2.33

0.87

0.0251

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016012

Sarcoglycan complex

2 of 5

2.78

1.04

0.0129

GOCC:0005927

Muscle tendon junction

2 of 6

2.7

1.04

0.0129

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05255

Uncharacterised protein family (UPF0220)

2 of 2

3.18

1.3

0.0046

PF04790

Sarcoglycan complex subunit protein

2 of 5

2.78

1.15

0.0081

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007919

Uncharacterised protein family UPF0220

2 of 2

3.18

1.02

0.0145

IPR039972

Sarcoglycan gamma/delta/zeta

2 of 4

2.88

0.97

0.0181

IPR006875

Sarcoglycan complex subunit protein

2 of 5

2.78

0.96

0.0181

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