SPATA6 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SPATA6

Spermatogenesis associated 6. (497 aa)

Predicted Functional Partners:

SNRPD1

0.982

SMN1

0.968

SNRPF

0.952

SNRPG

0.948

SNRPA1

0.947

SNRPD3

0.925

CLNS1A

0.899

GEMIN4

0.833

GEMIN5

0.817

DDX20

0.801

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLNS1A	GEMIN5	ENSAPLP00000006149	ENSAPLP00000006455	Uncharacterized protein.	Gem nuclear organelle associated protein 5.	0.436
CLNS1A	SMN1	ENSAPLP00000006149	ENSAPLP00000025318	Uncharacterized protein.	Tudor domain-containing protein.	0.912
CLNS1A	SNRPD1	ENSAPLP00000006149	ENSAPLP00000012020	Uncharacterized protein.	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family.	0.985
CLNS1A	SNRPD3	ENSAPLP00000006149	ENSAPLP00000008346	Uncharacterized protein.	Small nuclear ribonucleoprotein Sm D3.	0.907
CLNS1A	SNRPF	ENSAPLP00000006149	ENSAPLP00000025809	Uncharacterized protein.	Small nuclear ribonucleoprotein polypeptide F.	0.801
CLNS1A	SNRPG	ENSAPLP00000006149	ENSAPLP00000003436	Uncharacterized protein.	Small nuclear ribonucleoprotein polypeptide G.	0.791
CLNS1A	SPATA6	ENSAPLP00000006149	ENSAPLP00000022056	Uncharacterized protein.	Spermatogenesis associated 6.	0.899
DDX20	GEMIN4	ENSAPLP00000013658	ENSAPLP00000023160	DEAD-box helicase 20; Belongs to the DEAD box helicase family.	Gem nuclear organelle associated protein 4.	0.998
DDX20	GEMIN5	ENSAPLP00000013658	ENSAPLP00000006455	DEAD-box helicase 20; Belongs to the DEAD box helicase family.	Gem nuclear organelle associated protein 5.	0.998
DDX20	SMN1	ENSAPLP00000013658	ENSAPLP00000025318	DEAD-box helicase 20; Belongs to the DEAD box helicase family.	Tudor domain-containing protein.	0.998
DDX20	SNRPD1	ENSAPLP00000013658	ENSAPLP00000012020	DEAD-box helicase 20; Belongs to the DEAD box helicase family.	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family.	0.848
DDX20	SNRPD3	ENSAPLP00000013658	ENSAPLP00000008346	DEAD-box helicase 20; Belongs to the DEAD box helicase family.	Small nuclear ribonucleoprotein Sm D3.	0.810
DDX20	SNRPF	ENSAPLP00000013658	ENSAPLP00000025809	DEAD-box helicase 20; Belongs to the DEAD box helicase family.	Small nuclear ribonucleoprotein polypeptide F.	0.860
DDX20	SNRPG	ENSAPLP00000013658	ENSAPLP00000003436	DEAD-box helicase 20; Belongs to the DEAD box helicase family.	Small nuclear ribonucleoprotein polypeptide G.	0.803
DDX20	SPATA6	ENSAPLP00000013658	ENSAPLP00000022056	DEAD-box helicase 20; Belongs to the DEAD box helicase family.	Spermatogenesis associated 6.	0.801
GEMIN4	DDX20	ENSAPLP00000023160	ENSAPLP00000013658	Gem nuclear organelle associated protein 4.	DEAD-box helicase 20; Belongs to the DEAD box helicase family.	0.998
GEMIN4	GEMIN5	ENSAPLP00000023160	ENSAPLP00000006455	Gem nuclear organelle associated protein 4.	Gem nuclear organelle associated protein 5.	0.977
GEMIN4	SMN1	ENSAPLP00000023160	ENSAPLP00000025318	Gem nuclear organelle associated protein 4.	Tudor domain-containing protein.	0.977
GEMIN4	SNRPD1	ENSAPLP00000023160	ENSAPLP00000012020	Gem nuclear organelle associated protein 4.	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family.	0.708
GEMIN4	SNRPD3	ENSAPLP00000023160	ENSAPLP00000008346	Gem nuclear organelle associated protein 4.	Small nuclear ribonucleoprotein Sm D3.	0.737

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007186

G protein-coupled receptor signaling pathway

9 of 1311

1.1

1.21

1.12e-05

GO:0007165

Signal transduction

11 of 4180

0.68

0.59

0.00016

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030159

Signaling receptor complex adaptor activity

5 of 39

2.37

3.69

5.31e-08

GO:0031681

G-protein beta-subunit binding

3 of 24

2.36

1.95

0.00021

GO:0003924

GTPase activity

6 of 338

1.51

1.86

1.00e-05

GO:0051020

GTPase binding

4 of 279

1.42

1.07

0.0031

GO:0019899

Enzyme binding

6 of 1712

0.81

0.48

0.0297

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

7 of 36

2.55

6.58

5.97e-14

GO:0005886

Plasma membrane

10 of 4723

0.59

0.49

0.00055

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:32466321

(2020) Oviductal Extracellular Vesicles Improve Post-Thaw Sperm Function in Red Wolves and Cheetahs.

3 of 27

2.31

0.92

0.0201

PMID:19375447

(2009) Naturally occurring animal models with outer retina phenotypes.

3 of 24

2.36

0.92

0.0201

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18961

G beta:gamma signalling through BTK, and Phosducin

6 of 11

3.0

6.74

2.72e-13

CL:18951

G alpha (i) signalling events, and Inward rectifier potassium channel activity

8 of 131

2.05

4.9

1.49e-12

CL:18953

Mixed, incl. GABA B receptor activation, and Regulator of G protein signalling domain

7 of 98

2.12

4.66

2.87e-11

CL:18963

G beta:gamma signalling through BTK, and Serotonin receptors

4 of 6

3.09

4.53

4.99e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa04062

Chemokine signaling pathway

11 of 159

2.1

7.47

3.57e-21

cfa04727

GABAergic synapse

8 of 73

2.3

6.83

5.06e-16

cfa05032

Morphine addiction

8 of 77

2.28

6.75

5.41e-16

cfa04713

Circadian entrainment

8 of 85

2.24

6.52

1.00e-15

cfa04726

Serotonergic synapse

8 of 91

2.21

6.36

1.49e-15

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-8964315

G beta:gamma signalling through BTK

8 of 17

2.94

9.59

4.14e-19

CFA-8964616

G beta:gamma signalling through CDC42

8 of 19

2.89

9.51

4.24e-19

CFA-418217

G beta:gamma signalling through PLC beta

8 of 19

2.89

9.51

4.24e-19

CFA-500657

Presynaptic function of Kainate receptors

8 of 20

2.87

9.48

4.24e-19

CFA-400042

Adrenaline,noradrenaline inhibits insulin secretion

8 of 20

2.87

9.48

4.24e-19

(more ...)

WikiPathways

pathway

description

count in network

strength

signal

false discovery rate

WP1165

G protein signaling pathways

5 of 75

2.09

3.65

1.20e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

6 of 25

2.64

5.76

6.55e-12

GOCC:0031680

G-protein beta/gamma-subunit complex

2 of 5

2.87

1.65

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

5 of 244

1.58

1.75

4.89e-05

KW-0449

Lipoprotein

3 of 127

1.64

1.0

0.0085

KW-0807

Transducer

5 of 1006

0.96

0.61

0.0153

KW-0677

Repeat

5 of 1186

0.89

0.53

0.0249

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020472

G-protein beta WD-40 repeat

2 of 2

3.26

1.64

0.0011

IPR019775

WD40 repeat, conserved site

2 of 3

3.09

1.64

0.0011

IPR016346

Guanine nucleotide-binding protein, beta subunit

2 of 2

3.26

1.64

0.0011

IPR001632

G-protein, beta subunit

2 of 2

3.26

1.64

0.0011

IPR036322

WD40-repeat-containing domain superfamily

2 of 4

2.96

1.63

0.0011

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00224

G protein gamma subunit-like motifs

3 of 17

2.51

2.12

0.00011

SM00320

WD40 repeats

5 of 269

1.53

1.6

0.00011

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