NT5DC1 protein (Anas platyrhynchos) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

NT5DC1

5'-nucleotidase domain containing 1. (454 aa)

Predicted Functional Partners:

CALHM5

0.883

CALHM4

0.812

CALHM6

0.747

TRIB2

0.611

U3I5L3_ANAPP

0.594

GPRC6A

0.594

FAHD1

0.436

ABHD10

0.404

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD10	NT5DC1	ENSAPLP00000002496	ENSAPLP00000022304	Abhydrolase domain containing 10.	5'-nucleotidase domain containing 1.	0.404
CALHM4	GPRC6A	ENSAPLP00000010115	ENSAPLP00000028936	Uncharacterized protein.	ANF_receptor domain-containing protein.	0.592
CALHM4	NT5DC1	ENSAPLP00000010115	ENSAPLP00000022304	Uncharacterized protein.	5'-nucleotidase domain containing 1.	0.812
CALHM4	TRIB2	ENSAPLP00000010115	ENSAPLP00000012970	Uncharacterized protein.	Tribbles pseudokinase 2.	0.611
CALHM4	U3I5L3_ANAPP	ENSAPLP00000010115	ENSAPLP00000002534	Uncharacterized protein.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.592
CALHM5	GPRC6A	ENSAPLP00000010114	ENSAPLP00000028936	Calcium homeostasis modulator family member 5.	ANF_receptor domain-containing protein.	0.595
CALHM5	NT5DC1	ENSAPLP00000010114	ENSAPLP00000022304	Calcium homeostasis modulator family member 5.	5'-nucleotidase domain containing 1.	0.883
CALHM5	TRIB2	ENSAPLP00000010114	ENSAPLP00000012970	Calcium homeostasis modulator family member 5.	Tribbles pseudokinase 2.	0.611
CALHM5	U3I5L3_ANAPP	ENSAPLP00000010114	ENSAPLP00000002534	Calcium homeostasis modulator family member 5.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.595
CALHM6	NT5DC1	ENSAPLP00000010044	ENSAPLP00000022304	Calcium homeostasis modulator family member 6.	5'-nucleotidase domain containing 1.	0.747
CALHM6	TRIB2	ENSAPLP00000010044	ENSAPLP00000012970	Calcium homeostasis modulator family member 6.	Tribbles pseudokinase 2.	0.431
FAHD1	NT5DC1	ENSAPLP00000032816	ENSAPLP00000022304	Fumarylacetoacetate hydrolase domain containing 1.	5'-nucleotidase domain containing 1.	0.436
GPRC6A	CALHM4	ENSAPLP00000028936	ENSAPLP00000010115	ANF_receptor domain-containing protein.	Uncharacterized protein.	0.592
GPRC6A	CALHM5	ENSAPLP00000028936	ENSAPLP00000010114	ANF_receptor domain-containing protein.	Calcium homeostasis modulator family member 5.	0.595
GPRC6A	NT5DC1	ENSAPLP00000028936	ENSAPLP00000022304	ANF_receptor domain-containing protein.	5'-nucleotidase domain containing 1.	0.594
GPRC6A	U3I5L3_ANAPP	ENSAPLP00000028936	ENSAPLP00000002534	ANF_receptor domain-containing protein.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.925
NT5DC1	ABHD10	ENSAPLP00000022304	ENSAPLP00000002496	5'-nucleotidase domain containing 1.	Abhydrolase domain containing 10.	0.404
NT5DC1	CALHM4	ENSAPLP00000022304	ENSAPLP00000010115	5'-nucleotidase domain containing 1.	Uncharacterized protein.	0.812
NT5DC1	CALHM5	ENSAPLP00000022304	ENSAPLP00000010114	5'-nucleotidase domain containing 1.	Calcium homeostasis modulator family member 5.	0.883
NT5DC1	CALHM6	ENSAPLP00000022304	ENSAPLP00000010044	5'-nucleotidase domain containing 1.	Calcium homeostasis modulator family member 6.	0.747

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.782

expected number of edges:

13

PPI enrichment p-value:

1.62e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0150007

Clathrin-dependent synaptic vesicle endocytosis

4 of 7

3.07

3.89

7.75e-08

GO:0036465

Synaptic vesicle recycling

5 of 58

2.25

3.42

1.25e-07

GO:0060996

Dendritic spine development

3 of 16

2.59

2.3

5.40e-05

GO:0030032

Lamellipodium assembly

3 of 23

2.43

2.07

0.00013

GO:0120036

Plasma membrane bounded cell projection organization

6 of 998

1.1

0.91

0.0014

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005085

Guanyl-nucleotide exchange factor activity

7 of 263

1.74

2.92

2.51e-08

GO:0030695

GTPase regulator activity

8 of 555

1.48

2.31

2.66e-08

GO:0030234

Enzyme regulator activity

9 of 1134

1.22

1.65

6.36e-08

GO:0031267

Small GTPase binding

4 of 265

1.5

1.14

0.0026

GO:0060090

Molecular adaptor activity

4 of 369

1.35

0.92

0.0070

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005905

Clathrin-coated pit

4 of 60

2.14

2.47

1.14e-05

GO:0098793

Presynapse

5 of 396

1.42

1.4

0.00022

GO:0045202

Synapse

8 of 1097

1.18

1.38

5.29e-06

GO:0030027

Lamellipodium

3 of 140

1.65

0.98

0.0096

GO:0014069

Postsynaptic density

3 of 197

1.5

0.79

0.0217

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33082387

(2020) Unveiling the effect of dietary essential oils supplementation in Sparus aurata gills and its efficiency against the infestation by Sparicotyle chrysophrii.

2 of 13

2.5

0.96

0.0181

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12844

RHOU GTPase cycle, and RasGAP C-terminus

7 of 25

2.76

7.28

8.53e-15

CL:12847

p21 activated kinase binding domain, and Cytoplasmic protein NCK

5 of 11

2.98

5.65

3.22e-11

CL:12850

Unstructured region one on RhoGEF 6 and 7, and p21 activated kinase binding domain

4 of 6

3.14

4.64

3.37e-09

CL:14937

Clathrin-dependent endocytosis, and Clathrin coat

4 of 59

2.15

2.53

8.50e-06

CL:14956

Clathrin coat of coated pit, and Clathrin-dependent synaptic vesicle endocytosis

3 of 18

2.54

2.33

4.56e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04810

Regulation of actin cytoskeleton

4 of 239

1.54

1.37

0.00064

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9013420

RHOU GTPase cycle

11 of 53

2.63

11.83

5.54e-26

MAP-3928664

Ephrin signaling

5 of 22

2.67

5.07

1.98e-10

MAP-9013424

RHOV GTPase cycle

6 of 67

2.27

4.7

1.30e-10

MAP-9013406

RHOQ GTPase cycle

6 of 85

2.17

4.35

3.63e-10

MAP-9013148

CDC42 GTPase cycle

6 of 199

1.8

2.98

3.97e-08

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 13032

0.24

0.23

0.0187

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0728

SH3 domain

5 of 251

1.62

1.88

2.47e-05

KW-0723

Serine/threonine-protein kinase

3 of 233

1.43

0.73

0.0281

KW-0344

Guanine-nucleotide releasing factor

2 of 63

1.82

0.69

0.0479

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16614

Unstructured region two on RhoGEF 6 and 7

3 of 3

3.32

3.0

3.76e-06

PF16615

Unstructured region one on RhoGEF 6 and 7

2 of 2

3.32

1.59

0.0014

PF16523

betaPIX coiled coil

2 of 2

3.32

1.59

0.0014

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046376

RhoGEF 6/7, PH domain

3 of 3

3.32

2.99

3.91e-06

IPR000219

Dbl homology (DH) domain

5 of 91

2.06

2.62

3.77e-06

IPR035899

Dbl homology (DH) domain superfamily

5 of 93

2.05

2.61

3.77e-06

IPR033923

p21 activated kinase binding domain

3 of 7

2.95

2.61

1.76e-05

IPR036936

CRIB domain superfamily

3 of 12

2.72

2.32

5.33e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00285

P21-Rho-binding domain

3 of 17

2.56

2.35

4.26e-05

SM00325

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

4 of 80

2.02

2.14

4.26e-05

SM00326

Src homology 3 domains

5 of 258

1.6

1.8

4.26e-05

SM00233

Pleckstrin homology domain.

5 of 325

1.5

1.66

5.08e-05

SM00220

Serine/Threonine protein kinases, catalytic domain

3 of 273

1.36

0.64

0.0415

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