ENSAPLP00000023363 protein (Anas platyrhynchos)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

ENSAPLP00000023363

Ig-like domain-containing protein. (305 aa)

Predicted Functional Partners:

FEM1C

0.653

SH2D1A

0.635

IL20RB

0.616

AAGAB

0.611

FANCM

0.588

SPIRE2

0.578

CYB5R4

0.564

POLD2

0.545

SMN1

0.516

SNRPD1

0.490

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAGAB	ENSAPLP00000023363	ENSAPLP00000007002	ENSAPLP00000023363	Alpha and gamma adaptin binding protein.	Ig-like domain-containing protein.	0.611
AAGAB	FEM1C	ENSAPLP00000007002	ENSAPLP00000012647	Alpha and gamma adaptin binding protein.	Fem-1 homolog C.	0.749
CYB5R4	ENSAPLP00000023363	ENSAPLP00000011617	ENSAPLP00000023363	Cytochrome b5 reductase 4.	Ig-like domain-containing protein.	0.564
CYB5R4	IL20RB	ENSAPLP00000011617	ENSAPLP00000002704	Cytochrome b5 reductase 4.	Interleukin 20 receptor subunit beta.	0.611
CYB5R4	SPIRE2	ENSAPLP00000011617	ENSAPLP00000006675	Cytochrome b5 reductase 4.	Spire type actin nucleation factor 2.	0.587
ENSAPLP00000023363	AAGAB	ENSAPLP00000023363	ENSAPLP00000007002	Ig-like domain-containing protein.	Alpha and gamma adaptin binding protein.	0.611
ENSAPLP00000023363	CYB5R4	ENSAPLP00000023363	ENSAPLP00000011617	Ig-like domain-containing protein.	Cytochrome b5 reductase 4.	0.564
ENSAPLP00000023363	FANCM	ENSAPLP00000023363	ENSAPLP00000027475	Ig-like domain-containing protein.	FA complementation group M.	0.588
ENSAPLP00000023363	FEM1C	ENSAPLP00000023363	ENSAPLP00000012647	Ig-like domain-containing protein.	Fem-1 homolog C.	0.653
ENSAPLP00000023363	IL20RB	ENSAPLP00000023363	ENSAPLP00000002704	Ig-like domain-containing protein.	Interleukin 20 receptor subunit beta.	0.616
ENSAPLP00000023363	POLD2	ENSAPLP00000023363	ENSAPLP00000021348	Ig-like domain-containing protein.	DNA polymerase delta 2, accessory subunit.	0.545
ENSAPLP00000023363	SH2D1A	ENSAPLP00000023363	ENSAPLP00000012210	Ig-like domain-containing protein.	SH2 domain containing 1A.	0.635
ENSAPLP00000023363	SMN1	ENSAPLP00000023363	ENSAPLP00000025318	Ig-like domain-containing protein.	Tudor domain-containing protein.	0.516
ENSAPLP00000023363	SNRPD1	ENSAPLP00000023363	ENSAPLP00000012020	Ig-like domain-containing protein.	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family.	0.490
ENSAPLP00000023363	SPIRE2	ENSAPLP00000023363	ENSAPLP00000006675	Ig-like domain-containing protein.	Spire type actin nucleation factor 2.	0.578
FANCM	ENSAPLP00000023363	ENSAPLP00000027475	ENSAPLP00000023363	FA complementation group M.	Ig-like domain-containing protein.	0.588
FEM1C	AAGAB	ENSAPLP00000012647	ENSAPLP00000007002	Fem-1 homolog C.	Alpha and gamma adaptin binding protein.	0.749
FEM1C	ENSAPLP00000023363	ENSAPLP00000012647	ENSAPLP00000023363	Fem-1 homolog C.	Ig-like domain-containing protein.	0.653
IL20RB	CYB5R4	ENSAPLP00000002704	ENSAPLP00000011617	Interleukin 20 receptor subunit beta.	Cytochrome b5 reductase 4.	0.611
IL20RB	ENSAPLP00000023363	ENSAPLP00000002704	ENSAPLP00000023363	Interleukin 20 receptor subunit beta.	Ig-like domain-containing protein.	0.616

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

11

PPI enrichment p-value:

3.84e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006525

Arginine metabolic process

11 of 34

2.23

8.23

2.82e-21

GO:0006526

Arginine biosynthetic process

9 of 17

2.45

8.04

4.90e-18

GO:0006591

Ornithine metabolic process

4 of 6

2.55

3.56

1.65e-07

GO:0042450

Arginine biosynthetic process via ornithine

2 of 2

2.72

1.57

0.0014

GO:0044205

De novo UMP biosynthetic process

2 of 7

2.18

1.12

0.0079

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0103045

Methione N-acyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0004088

Carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

2 of 2

2.72

0.93

0.0203

GO:0004042

acetyl-CoA:L-glutamate N-acetyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0016774

Phosphotransferase activity, carboxyl group as acceptor

2 of 7

2.18

0.82

0.0303

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

3 of 51

1.49

0.73

0.0303

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1829

0.5

0.42

0.00052

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1505

Arginine biosynthesis, and Amino acid antiporter

9 of 15

2.5

8.22

4.37e-18

CL:1510

Arginine biosynthesis

6 of 6

2.72

6.12

1.70e-12

CL:1367

Cellular amino acid biosynthetic process, and Ribonucleoside monophosphate biosynthetic process

11 of 152

1.58

3.6

3.78e-15

CL:1525

Amino acid antiporter, and Arginine catabolic process to ornithine

2 of 5

2.33

1.03

0.0127

CL:1578

Pyrimidine biosynthesis, and Dihydroorotase, conserved site

2 of 6

2.25

0.99

0.0148

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pfn00220

Arginine biosynthesis

9 of 36

2.12

6.25

3.12e-16

pfn00250

Alanine, aspartate and glutamate metabolism

4 of 39

1.74

1.95

3.78e-05

pfn01230

Biosynthesis of amino acids

7 of 179

1.32

1.75

6.17e-07

pfn01210

2-Oxocarboxylic acid metabolism

4 of 51

1.62

1.75

6.84e-05

pfn01110

Biosynthesis of secondary metabolites

8 of 614

0.84

0.78

6.84e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005951

Carbamoyl-phosphate synthase complex

2 of 2

2.72

1.18

0.0073

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0055

Arginine biosynthesis

9 of 13

2.56

8.87

2.96e-19

KW-0963

Cytoplasm

8 of 311

1.13

1.38

8.14e-07

KW-0665

Pyrimidine biosynthesis

2 of 10

2.03

1.0

0.0124

KW-0436

Ligase

3 of 73

1.34

0.8

0.0152

KW-0808

Transferase

5 of 407

0.81

0.51

0.0216

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00696

Amino acid kinase family

3 of 6

2.42

1.85

0.00035

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036393

Acetylglutamate kinase-like superfamily

3 of 6

2.42

1.71

0.00065

IPR001048

Aspartate/glutamate/uridylate kinase

3 of 6

2.42

1.71

0.00065

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