RACK1 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

RACK1

WD_REPEATS_REGION domain-containing protein. (101 aa)

Predicted Functional Partners:

FAU

0.990

ENSAPLP00000016784

0.900

ENSAPLP00000022550

0.900

RPS3

0.890

RPS20

0.889

RPS2

0.888

RPS24

0.888

RPS10

0.882

RPS7

0.880

RPS25

0.877

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAPLP00000016784	FAU	ENSAPLP00000016784	ENSAPLP00000027823	WD_REPEATS_REGION domain-containing protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.990
ENSAPLP00000016784	RACK1	ENSAPLP00000016784	ENSAPLP00000023415	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.900
ENSAPLP00000016784	RPS10	ENSAPLP00000016784	ENSAPLP00000029768	WD_REPEATS_REGION domain-containing protein.	Ribosomal protein S10.	0.882
ENSAPLP00000016784	RPS2	ENSAPLP00000016784	ENSAPLP00000008154	WD_REPEATS_REGION domain-containing protein.	Ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family.	0.888
ENSAPLP00000016784	RPS20	ENSAPLP00000016784	ENSAPLP00000006691	WD_REPEATS_REGION domain-containing protein.	Ribosomal_S10 domain-containing protein.	0.889
ENSAPLP00000016784	RPS24	ENSAPLP00000016784	ENSAPLP00000021570	WD_REPEATS_REGION domain-containing protein.	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	0.888
ENSAPLP00000016784	RPS25	ENSAPLP00000016784	ENSAPLP00000027821	WD_REPEATS_REGION domain-containing protein.	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family.	0.877
ENSAPLP00000016784	RPS3	ENSAPLP00000016784	ENSAPLP00000014372	WD_REPEATS_REGION domain-containing protein.	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family.	0.890
ENSAPLP00000016784	RPS7	ENSAPLP00000016784	ENSAPLP00000001900	WD_REPEATS_REGION domain-containing protein.	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family.	0.880
ENSAPLP00000022550	FAU	ENSAPLP00000022550	ENSAPLP00000027823	WD_REPEATS_REGION domain-containing protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.990
ENSAPLP00000022550	RACK1	ENSAPLP00000022550	ENSAPLP00000023415	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.900
ENSAPLP00000022550	RPS10	ENSAPLP00000022550	ENSAPLP00000029768	WD_REPEATS_REGION domain-containing protein.	Ribosomal protein S10.	0.882
ENSAPLP00000022550	RPS2	ENSAPLP00000022550	ENSAPLP00000008154	WD_REPEATS_REGION domain-containing protein.	Ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family.	0.888
ENSAPLP00000022550	RPS20	ENSAPLP00000022550	ENSAPLP00000006691	WD_REPEATS_REGION domain-containing protein.	Ribosomal_S10 domain-containing protein.	0.889
ENSAPLP00000022550	RPS24	ENSAPLP00000022550	ENSAPLP00000021570	WD_REPEATS_REGION domain-containing protein.	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	0.888
ENSAPLP00000022550	RPS25	ENSAPLP00000022550	ENSAPLP00000027821	WD_REPEATS_REGION domain-containing protein.	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family.	0.877
ENSAPLP00000022550	RPS3	ENSAPLP00000022550	ENSAPLP00000014372	WD_REPEATS_REGION domain-containing protein.	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family.	0.890
ENSAPLP00000022550	RPS7	ENSAPLP00000022550	ENSAPLP00000001900	WD_REPEATS_REGION domain-containing protein.	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family.	0.880
FAU	ENSAPLP00000016784	ENSAPLP00000027823	ENSAPLP00000016784	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	WD_REPEATS_REGION domain-containing protein.	0.990
FAU	ENSAPLP00000022550	ENSAPLP00000027823	ENSAPLP00000022550	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	WD_REPEATS_REGION domain-containing protein.	0.990

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Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.723

expected number of edges:

12

PPI enrichment p-value:

4.03e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007005

Mitochondrion organization

7 of 182

1.51

2.06

1.39e-06

GO:0006626

Protein targeting to mitochondrion

4 of 41

1.92

1.74

0.00027

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 7

2.38

1.08

0.0101

GO:0015031

Protein transport

6 of 381

1.12

0.96

0.0011

GO:0033617

Mitochondrial cytochrome c oxidase assembly

2 of 19

1.95

0.74

0.0408

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015035

Protein-disulfide reductase activity

3 of 17

2.17

1.41

0.0021

GO:0140318

Protein transporter activity

3 of 22

2.06

1.39

0.0021

GO:0016972

Thiol oxidase activity

2 of 3

2.75

1.28

0.0048

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005758

Mitochondrial intermembrane space

6 of 41

2.09

3.82

4.29e-09

GO:0005740

Mitochondrial envelope

9 of 329

1.36

2.14

4.29e-09

GO:0005743

Mitochondrial inner membrane

7 of 226

1.42

2.03

2.05e-07

GO:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 2

2.93

1.78

0.00058

GO:0005739

Mitochondrion

10 of 874

0.99

1.16

8.02e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13036

Protein targeting to mitochondrion, and Tim10-like

8 of 29

2.37

6.85

1.51e-15

CL:13032

Mixed, incl. Protein localization to mitochondrion, and Respiratory chain complex IV assembly

10 of 70

2.08

6.4

2.23e-17

CL:13083

Protein import into mitochondrial intermembrane space, and Tim10-like

4 of 5

2.83

4.04

3.17e-08

CL:13038

TIM23 mitochondrial import inner membrane translocase complex, and TIM22 mitochondrial import inner membrane insertion complex

3 of 14

2.26

1.97

0.00017

CL:13054

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

2 of 6

2.45

1.21

0.0059

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

9 of 50

2.18

6.44

4.37e-16

MAP-9609507

Protein localization

9 of 239

1.5

2.73

1.41e-10

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005758

Mitochondrial intermembrane space

8 of 48

2.15

5.5

1.62e-13

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

4 of 4

2.93

4.23

1.58e-08

GOCC:0005740

Mitochondrial envelope

9 of 310

1.39

2.28

9.81e-10

GOCC:0098798

Mitochondrial protein complex

5 of 168

1.4

1.5

7.20e-05

GOCC:0043231

Intracellular membrane-bounded organelle

11 of 2850

0.51

0.44

0.00017

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1015

Disulfide bond

6 of 29

2.24

4.58

1.98e-10

KW-0811

Translocation

4 of 9

2.58

3.7

9.09e-08

KW-0496

Mitochondrion

4 of 108

1.5

1.41

0.00037

KW-0143

Chaperone

2 of 22

1.89

0.96

0.0140

KW-0862

Zinc

4 of 343

0.99

0.62

0.0176

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02953

Tim10/DDP family zinc finger

4 of 4

2.93

3.88

7.12e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR035427

Tim10-like domain superfamily

4 of 4

2.93

3.64

2.03e-07

IPR004217

Tim10-like

4 of 4

2.93

3.64

2.03e-07

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