GINS3 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GINS3

GINS complex subunit 3. (214 aa)

Predicted Functional Partners:

GINS2

0.998

GINS4

0.997

MCM4

0.989

MCM5

0.989

CDC45

0.989

MCM2

0.987

MCM3

0.987

MCM6

0.986

WDHD1

0.977

POLE2

0.942

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC45	GINS2	ENSAPLP00000020547	ENSAPLP00000026162	Cell division cycle 45.	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	0.994
CDC45	GINS3	ENSAPLP00000020547	ENSAPLP00000023735	Cell division cycle 45.	GINS complex subunit 3.	0.989
CDC45	GINS4	ENSAPLP00000020547	ENSAPLP00000020652	Cell division cycle 45.	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.	0.988
CDC45	MCM2	ENSAPLP00000020547	ENSAPLP00000004081	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.999
CDC45	MCM3	ENSAPLP00000020547	ENSAPLP00000012910	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.999
CDC45	MCM4	ENSAPLP00000020547	ENSAPLP00000002992	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.999
CDC45	MCM5	ENSAPLP00000020547	ENSAPLP00000007633	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.999
CDC45	MCM6	ENSAPLP00000020547	ENSAPLP00000016276	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.999
CDC45	POLE2	ENSAPLP00000020547	ENSAPLP00000007103	Cell division cycle 45.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.992
CDC45	WDHD1	ENSAPLP00000020547	ENSAPLP00000024272	Cell division cycle 45.	HMG box domain-containing protein.	0.987
GINS2	CDC45	ENSAPLP00000026162	ENSAPLP00000020547	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	Cell division cycle 45.	0.994
GINS2	GINS3	ENSAPLP00000026162	ENSAPLP00000023735	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	GINS complex subunit 3.	0.998
GINS2	GINS4	ENSAPLP00000026162	ENSAPLP00000020652	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.	0.997
GINS2	MCM2	ENSAPLP00000026162	ENSAPLP00000004081	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	DNA helicase; Belongs to the MCM family.	0.990
GINS2	MCM3	ENSAPLP00000026162	ENSAPLP00000012910	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	DNA helicase; Belongs to the MCM family.	0.989
GINS2	MCM4	ENSAPLP00000026162	ENSAPLP00000002992	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	DNA helicase; Belongs to the MCM family.	0.990
GINS2	MCM5	ENSAPLP00000026162	ENSAPLP00000007633	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	DNA helicase; Belongs to the MCM family.	0.989
GINS2	MCM6	ENSAPLP00000026162	ENSAPLP00000016276	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	DNA helicase; Belongs to the MCM family.	0.988
GINS2	POLE2	ENSAPLP00000026162	ENSAPLP00000007103	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.966
GINS2	WDHD1	ENSAPLP00000026162	ENSAPLP00000024272	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	HMG box domain-containing protein.	0.974

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.782

expected number of edges:

13

PPI enrichment p-value:

1.62e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0150007

Clathrin-dependent synaptic vesicle endocytosis

4 of 7

3.07

3.89

7.75e-08

GO:0036465

Synaptic vesicle recycling

5 of 58

2.25

3.42

1.25e-07

GO:0060996

Dendritic spine development

3 of 16

2.59

2.3

5.40e-05

GO:0030032

Lamellipodium assembly

3 of 23

2.43

2.07

0.00013

GO:0120036

Plasma membrane bounded cell projection organization

6 of 998

1.1

0.91

0.0014

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005085

Guanyl-nucleotide exchange factor activity

7 of 263

1.74

2.92

2.51e-08

GO:0030695

GTPase regulator activity

8 of 555

1.48

2.31

2.66e-08

GO:0030234

Enzyme regulator activity

9 of 1134

1.22

1.65

6.36e-08

GO:0031267

Small GTPase binding

4 of 265

1.5

1.14

0.0026

GO:0060090

Molecular adaptor activity

4 of 369

1.35

0.92

0.0070

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005905

Clathrin-coated pit

4 of 60

2.14

2.47

1.14e-05

GO:0098793

Presynapse

5 of 396

1.42

1.4

0.00022

GO:0045202

Synapse

8 of 1097

1.18

1.38

5.29e-06

GO:0030027

Lamellipodium

3 of 140

1.65

0.98

0.0096

GO:0014069

Postsynaptic density

3 of 197

1.5

0.79

0.0217

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33082387

(2020) Unveiling the effect of dietary essential oils supplementation in Sparus aurata gills and its efficiency against the infestation by Sparicotyle chrysophrii.

2 of 13

2.5

0.96

0.0181

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12844

RHOU GTPase cycle, and RasGAP C-terminus

7 of 25

2.76

7.28

8.53e-15

CL:12847

p21 activated kinase binding domain, and Cytoplasmic protein NCK

5 of 11

2.98

5.65

3.22e-11

CL:12850

Unstructured region one on RhoGEF 6 and 7, and p21 activated kinase binding domain

4 of 6

3.14

4.64

3.37e-09

CL:14937

Clathrin-dependent endocytosis, and Clathrin coat

4 of 59

2.15

2.53

8.50e-06

CL:14956

Clathrin coat of coated pit, and Clathrin-dependent synaptic vesicle endocytosis

3 of 18

2.54

2.33

4.56e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret04810

Regulation of actin cytoskeleton

4 of 239

1.54

1.37

0.00064

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9013420

RHOU GTPase cycle

11 of 53

2.63

11.83

5.54e-26

MAP-3928664

Ephrin signaling

5 of 22

2.67

5.07

1.98e-10

MAP-9013424

RHOV GTPase cycle

6 of 67

2.27

4.7

1.30e-10

MAP-9013406

RHOQ GTPase cycle

6 of 85

2.17

4.35

3.63e-10

MAP-9013148

CDC42 GTPase cycle

6 of 199

1.8

2.98

3.97e-08

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 13032

0.24

0.23

0.0187

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0728

SH3 domain

5 of 251

1.62

1.88

2.47e-05

KW-0723

Serine/threonine-protein kinase

3 of 233

1.43

0.73

0.0281

KW-0344

Guanine-nucleotide releasing factor

2 of 63

1.82

0.69

0.0479

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16614

Unstructured region two on RhoGEF 6 and 7

3 of 3

3.32

3.0

3.76e-06

PF16615

Unstructured region one on RhoGEF 6 and 7

2 of 2

3.32

1.59

0.0014

PF16523

betaPIX coiled coil

2 of 2

3.32

1.59

0.0014

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046376

RhoGEF 6/7, PH domain

3 of 3

3.32

2.99

3.91e-06

IPR000219

Dbl homology (DH) domain

5 of 91

2.06

2.62

3.77e-06

IPR035899

Dbl homology (DH) domain superfamily

5 of 93

2.05

2.61

3.77e-06

IPR033923

p21 activated kinase binding domain

3 of 7

2.95

2.61

1.76e-05

IPR036936

CRIB domain superfamily

3 of 12

2.72

2.32

5.33e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00285

P21-Rho-binding domain

3 of 17

2.56

2.35

4.26e-05

SM00325

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

4 of 80

2.02

2.14

4.26e-05

SM00326

Src homology 3 domains

5 of 258

1.6

1.8

4.26e-05

SM00233

Pleckstrin homology domain.

5 of 325

1.5

1.66

5.08e-05

SM00220

Serine/Threonine protein kinases, catalytic domain

3 of 273

1.36

0.64

0.0415

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