STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (341 aa)    
Predicted Functional Partners:
CACYBP
Calcyclin binding protein.
    
 0.983
CTNNB1
Catenin beta 1.
    
 0.936
UBE2V2
Ubiquitin conjugating enzyme E2 V2.
    
   0.644
U3J5I9_ANAPP
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.621
USP13
Ubiquitin carboxyl-terminal hydrolase.
    
 0.608
USP19
Ubiquitin specific peptidase 19.
    
 
 0.596
AXIN1
Axin 1.
    
 0.577
USP5
Ubiquitin carboxyl-terminal hydrolase.
    
 0.547
SNCA
Alpha-synuclein; Belongs to the synuclein family.
    
 0.529
ENSAPLP00000028196
Gp_dh_C domain-containing protein.
   
 
 0.495
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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