PAPPA protein (Anas platyrhynchos) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Score

PAPPA

Pappalysin 1. (1627 aa)

Predicted Functional Partners:

ENSAPLP00000032361

0.553

CMSS1

0.548

AVEN

0.499

AARS1

0.499

IGF2R

0.479

ADGRA3

0.454

IGFBP3

0.414

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AARS1	AVEN	ENSAPLP00000008235	ENSAPLP00000004654	Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.	Apoptosis and caspase activation inhibitor.	0.499
AARS1	PAPPA	ENSAPLP00000008235	ENSAPLP00000023916	Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.	Pappalysin 1.	0.499
ADGRA3	CMSS1	ENSAPLP00000008801	ENSAPLP00000010349	Adhesion G protein-coupled receptor A3; Belongs to the G-protein coupled receptor 2 family.	Cms1 ribosomal small subunit homolog.	0.611
ADGRA3	PAPPA	ENSAPLP00000008801	ENSAPLP00000023916	Adhesion G protein-coupled receptor A3; Belongs to the G-protein coupled receptor 2 family.	Pappalysin 1.	0.454
AVEN	AARS1	ENSAPLP00000004654	ENSAPLP00000008235	Apoptosis and caspase activation inhibitor.	Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.	0.499
AVEN	PAPPA	ENSAPLP00000004654	ENSAPLP00000023916	Apoptosis and caspase activation inhibitor.	Pappalysin 1.	0.499
CMSS1	ADGRA3	ENSAPLP00000010349	ENSAPLP00000008801	Cms1 ribosomal small subunit homolog.	Adhesion G protein-coupled receptor A3; Belongs to the G-protein coupled receptor 2 family.	0.611
CMSS1	PAPPA	ENSAPLP00000010349	ENSAPLP00000023916	Cms1 ribosomal small subunit homolog.	Pappalysin 1.	0.548
ENSAPLP00000032361	PAPPA	ENSAPLP00000032361	ENSAPLP00000023916	IGFBP N-terminal domain-containing protein.	Pappalysin 1.	0.553
IGF2R	PAPPA	ENSAPLP00000006868	ENSAPLP00000023916	Insulin like growth factor 2 receptor.	Pappalysin 1.	0.479
IGFBP3	PAPPA	ENSAPLP00000016279	ENSAPLP00000023916	Insulin like growth factor binding protein 3.	Pappalysin 1.	0.414
PAPPA	AARS1	ENSAPLP00000023916	ENSAPLP00000008235	Pappalysin 1.	Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.	0.499
PAPPA	ADGRA3	ENSAPLP00000023916	ENSAPLP00000008801	Pappalysin 1.	Adhesion G protein-coupled receptor A3; Belongs to the G-protein coupled receptor 2 family.	0.454
PAPPA	AVEN	ENSAPLP00000023916	ENSAPLP00000004654	Pappalysin 1.	Apoptosis and caspase activation inhibitor.	0.499
PAPPA	CMSS1	ENSAPLP00000023916	ENSAPLP00000010349	Pappalysin 1.	Cms1 ribosomal small subunit homolog.	0.548
PAPPA	ENSAPLP00000032361	ENSAPLP00000023916	ENSAPLP00000032361	Pappalysin 1.	IGFBP N-terminal domain-containing protein.	0.553
PAPPA	IGF2R	ENSAPLP00000023916	ENSAPLP00000006868	Pappalysin 1.	Insulin like growth factor 2 receptor.	0.479
PAPPA	IGFBP3	ENSAPLP00000023916	ENSAPLP00000016279	Pappalysin 1.	Insulin like growth factor binding protein 3.	0.414

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.837

expected number of edges:

13

PPI enrichment p-value:

0.00571

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0048643

Positive regulation of skeletal muscle tissue development

4 of 8

2.88

3.63

2.02e-07

GO:0048743

Positive regulation of skeletal muscle fiber development

3 of 4

3.05

2.97

4.00e-06

GO:0042693

Muscle cell fate commitment

3 of 12

2.58

2.37

3.83e-05

GO:0045663

Positive regulation of myoblast differentiation

3 of 15

2.48

2.25

6.08e-05

GO:0045165

Cell fate commitment

5 of 150

1.7

2.07

1.25e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070888

E-box binding

4 of 28

2.33

2.77

4.38e-06

GO:0043425

bHLH transcription factor binding

3 of 18

2.4

2.12

0.00010

GO:0046983

Protein dimerization activity

9 of 690

1.29

1.84

5.31e-08

GO:0140297

DNA-binding transcription factor binding

5 of 288

1.42

1.44

0.00015

GO:0000978

RNA polymerase II cis-regulatory region sequence-specific DNA binding

7 of 732

1.16

1.2

6.27e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

7 of 333

1.5

2.12

5.73e-07

GO:0005634

Nucleus

11 of 5262

0.5

0.4

0.0021

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:38003577

(2023) Whole-Transcriptome RNA Sequencing Uncovers the Global Expression Changes and RNA Regulatory Networks in Duck Embryonic Myogenesis.

2 of 6

2.7

1.08

0.0112

PMID:37729680

(2023) Dietary zinc supplementation in breeding pigeons improves the carcass traits of squabs through regulating antioxidant capacity and myogenic regulatory factor expression.

2 of 3

3.0

1.08

0.0112

PMID:37170512

(2023) Current technologies, regulation, and future perspective of animal product analogs - A review.

2 of 4

2.88

1.08

0.0112

PMID:37108828

(2023) Sow-Offspring Diets Supplemented with Probiotics and Synbiotics Are Associated with Offsprings Growth Performance and Meat Quality.

2 of 5

2.78

1.08

0.0112

PMID:36697366

(2023) Genome-wide association studies demonstrate the genes associated with perimysial thickness in ducks.

2 of 4

2.88

1.08

0.0112

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:22056

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and DNA-binding protein inhibitor

7 of 17

2.79

7.53

3.02e-15

CL:21810

DNA-binding transcription factor activity, RNA polymerase II-specific, and DNA-binding protein inhibitor

10 of 162

1.97

5.57

4.34e-16

CL:22058

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and Runx inhibition domain

4 of 11

2.74

3.82

7.45e-08

CL:22080

DNA-binding protein inhibitor, and E-box binding

3 of 5

2.96

2.88

5.56e-06

CL:21814

Mixed, incl. Myogenesis, and Sox developmental protein N-terminal

3 of 34

2.12

1.64

0.00068

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-525793

Myogenesis

7 of 37

2.46

6.11

3.01e-13

MAP-1266738

Developmental Biology

7 of 573

1.27

1.45

1.48e-05

MAP-2559585

Oncogene Induced Senescence

2 of 11

2.44

0.96

0.0172

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005634

Nucleus

9 of 2704

0.7

0.51

0.0050

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12232

Myogenic determination factor 5

2 of 2

3.18

1.3

0.0046

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036638

Helix-loop-helix DNA-binding domain superfamily

6 of 85

2.03

3.29

6.24e-08

IPR011598

Myc-type, basic helix-loop-helix (bHLH) domain

6 of 85

2.03

3.29

6.24e-08

IPR039704

Myogenic factor

3 of 3

3.18

2.79

8.71e-06

IPR002546

Myogenic muscle-specific protein, N-terminal

3 of 3

3.18

2.79

8.71e-06

IPR022032

Myogenic determination factor 5

2 of 2

3.18

1.41

0.0029

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00353

Helix loop helix domain

6 of 89

2.01

3.55

9.76e-09

SM00520

Basic domain in HLH proteins of MYOD family

3 of 3

3.18

3.2

1.57e-06

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