ENSAPLP00000024125 protein (Anas platyrhynchos)

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second shell of interactors

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Known Interactions

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Predicted Interactions

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ENSAPLP00000024125

Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (298 aa)

Predicted Functional Partners:

CRYBA1

0.538

U3IFY7_ANAPP

0.504

GJA1

0.503

ENSAPLP00000020996

0.495

GJA4

0.490

U3HYU0_ANAPP

0.480

CLDN5

0.470

GJC2

0.467

GJB1

0.460

ENSAPLP00000020537

0.452

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLDN5	ENSAPLP00000020537	ENSAPLP00000029125	ENSAPLP00000020537	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.497
CLDN5	ENSAPLP00000020996	ENSAPLP00000029125	ENSAPLP00000020996	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.499
CLDN5	ENSAPLP00000024125	ENSAPLP00000029125	ENSAPLP00000024125	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.470
CLDN5	GJA1	ENSAPLP00000029125	ENSAPLP00000000131	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.485
CLDN5	U3IFY7_ANAPP	ENSAPLP00000029125	ENSAPLP00000006159	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.827
CRYBA1	ENSAPLP00000024125	ENSAPLP00000027605	ENSAPLP00000024125	Crystallin beta A1; Belongs to the beta/gamma-crystallin family.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.538
ENSAPLP00000020537	CLDN5	ENSAPLP00000020537	ENSAPLP00000029125	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.497
ENSAPLP00000020537	ENSAPLP00000020996	ENSAPLP00000020537	ENSAPLP00000020996	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Uncharacterized protein.	0.522
ENSAPLP00000020537	ENSAPLP00000024125	ENSAPLP00000020537	ENSAPLP00000024125	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.452
ENSAPLP00000020537	GJA1	ENSAPLP00000020537	ENSAPLP00000000131	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.500
ENSAPLP00000020537	GJA4	ENSAPLP00000020537	ENSAPLP00000001180	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.529
ENSAPLP00000020537	GJB1	ENSAPLP00000020537	ENSAPLP00000000675	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.720
ENSAPLP00000020537	GJC2	ENSAPLP00000020537	ENSAPLP00000000114	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.518
ENSAPLP00000020537	U3HYU0_ANAPP	ENSAPLP00000020537	ENSAPLP00000000160	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.767
ENSAPLP00000020537	U3IFY7_ANAPP	ENSAPLP00000020537	ENSAPLP00000006159	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Uncharacterized protein.	0.534
ENSAPLP00000020996	CLDN5	ENSAPLP00000020996	ENSAPLP00000029125	Uncharacterized protein.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.499
ENSAPLP00000020996	ENSAPLP00000020537	ENSAPLP00000020996	ENSAPLP00000020537	Uncharacterized protein.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.522
ENSAPLP00000020996	ENSAPLP00000024125	ENSAPLP00000020996	ENSAPLP00000024125	Uncharacterized protein.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.495
ENSAPLP00000020996	U3HYU0_ANAPP	ENSAPLP00000020996	ENSAPLP00000000160	Uncharacterized protein.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.486
ENSAPLP00000020996	U3IFY7_ANAPP	ENSAPLP00000020996	ENSAPLP00000006159	Uncharacterized protein.	Uncharacterized protein.	0.523

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.723

expected number of edges:

12

PPI enrichment p-value:

4.03e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007005

Mitochondrion organization

7 of 182

1.51

2.06

1.39e-06

GO:0006626

Protein targeting to mitochondrion

4 of 41

1.92

1.74

0.00027

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 7

2.38

1.08

0.0101

GO:0015031

Protein transport

6 of 381

1.12

0.96

0.0011

GO:0033617

Mitochondrial cytochrome c oxidase assembly

2 of 19

1.95

0.74

0.0408

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015035

Protein-disulfide reductase activity

3 of 17

2.17

1.41

0.0021

GO:0140318

Protein transporter activity

3 of 22

2.06

1.39

0.0021

GO:0016972

Thiol oxidase activity

2 of 3

2.75

1.28

0.0048

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005758

Mitochondrial intermembrane space

6 of 41

2.09

3.82

4.29e-09

GO:0005740

Mitochondrial envelope

9 of 329

1.36

2.14

4.29e-09

GO:0005743

Mitochondrial inner membrane

7 of 226

1.42

2.03

2.05e-07

GO:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 2

2.93

1.78

0.00058

GO:0005739

Mitochondrion

10 of 874

0.99

1.16

8.02e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13036

Protein targeting to mitochondrion, and Tim10-like

8 of 29

2.37

6.85

1.51e-15

CL:13032

Mixed, incl. Protein localization to mitochondrion, and Respiratory chain complex IV assembly

10 of 70

2.08

6.4

2.23e-17

CL:13083

Protein import into mitochondrial intermembrane space, and Tim10-like

4 of 5

2.83

4.04

3.17e-08

CL:13038

TIM23 mitochondrial import inner membrane translocase complex, and TIM22 mitochondrial import inner membrane insertion complex

3 of 14

2.26

1.97

0.00017

CL:13054

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

2 of 6

2.45

1.21

0.0059

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

9 of 50

2.18

6.44

4.37e-16

MAP-9609507

Protein localization

9 of 239

1.5

2.73

1.41e-10

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005758

Mitochondrial intermembrane space

8 of 48

2.15

5.5

1.62e-13

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

4 of 4

2.93

4.23

1.58e-08

GOCC:0005740

Mitochondrial envelope

9 of 310

1.39

2.28

9.81e-10

GOCC:0098798

Mitochondrial protein complex

5 of 168

1.4

1.5

7.20e-05

GOCC:0043231

Intracellular membrane-bounded organelle

11 of 2850

0.51

0.44

0.00017

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1015

Disulfide bond

6 of 29

2.24

4.58

1.98e-10

KW-0811

Translocation

4 of 9

2.58

3.7

9.09e-08

KW-0496

Mitochondrion

4 of 108

1.5

1.41

0.00037

KW-0143

Chaperone

2 of 22

1.89

0.96

0.0140

KW-0862

Zinc

4 of 343

0.99

0.62

0.0176

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02953

Tim10/DDP family zinc finger

4 of 4

2.93

3.88

7.12e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR035427

Tim10-like domain superfamily

4 of 4

2.93

3.64

2.03e-07

IPR004217

Tim10-like

4 of 4

2.93

3.64

2.03e-07

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