HNF4A protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HNF4A

Hepatocyte nuclear factor 4 alpha. (481 aa)

Predicted Functional Partners:

HNF1A

0.841

FOXA2

0.737

C2H9orf152

0.645

PPARGC1A

0.618

SGPL1

0.612

INS

0.587

NR0B2

0.577

U3IDX4_ANAPP

0.567

KRT15

0.544

LPIN1

0.533

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C2H9orf152	HNF4A	ENSAPLP00000012979	ENSAPLP00000024308	DUF4682 domain-containing protein.	Hepatocyte nuclear factor 4 alpha.	0.645
FOXA2	HNF1A	ENSAPLP00000025594	ENSAPLP00000002032	Forkhead box A2.	Homeobox domain-containing protein.	0.505
FOXA2	HNF4A	ENSAPLP00000025594	ENSAPLP00000024308	Forkhead box A2.	Hepatocyte nuclear factor 4 alpha.	0.737
FOXA2	INS	ENSAPLP00000025594	ENSAPLP00000012854	Forkhead box A2.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.548
HNF1A	FOXA2	ENSAPLP00000002032	ENSAPLP00000025594	Homeobox domain-containing protein.	Forkhead box A2.	0.505
HNF1A	HNF4A	ENSAPLP00000002032	ENSAPLP00000024308	Homeobox domain-containing protein.	Hepatocyte nuclear factor 4 alpha.	0.841
HNF1A	INS	ENSAPLP00000002032	ENSAPLP00000012854	Homeobox domain-containing protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.403
HNF4A	C2H9orf152	ENSAPLP00000024308	ENSAPLP00000012979	Hepatocyte nuclear factor 4 alpha.	DUF4682 domain-containing protein.	0.645
HNF4A	FOXA2	ENSAPLP00000024308	ENSAPLP00000025594	Hepatocyte nuclear factor 4 alpha.	Forkhead box A2.	0.737
HNF4A	HNF1A	ENSAPLP00000024308	ENSAPLP00000002032	Hepatocyte nuclear factor 4 alpha.	Homeobox domain-containing protein.	0.841
HNF4A	INS	ENSAPLP00000024308	ENSAPLP00000012854	Hepatocyte nuclear factor 4 alpha.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.587
HNF4A	KRT15	ENSAPLP00000024308	ENSAPLP00000008717	Hepatocyte nuclear factor 4 alpha.	Keratin 15; Belongs to the intermediate filament family.	0.544
HNF4A	LPIN1	ENSAPLP00000024308	ENSAPLP00000020013	Hepatocyte nuclear factor 4 alpha.	Lipin 1.	0.533
HNF4A	NR0B2	ENSAPLP00000024308	ENSAPLP00000010462	Hepatocyte nuclear factor 4 alpha.	Nuclear receptor subfamily 0 group B member 2.	0.577
HNF4A	PPARGC1A	ENSAPLP00000024308	ENSAPLP00000031219	Hepatocyte nuclear factor 4 alpha.	PPARG coactivator 1 alpha.	0.618
HNF4A	SGPL1	ENSAPLP00000024308	ENSAPLP00000031665	Hepatocyte nuclear factor 4 alpha.	Sphingosine-1-phosphate lyase 1.	0.612
HNF4A	U3IDX4_ANAPP	ENSAPLP00000024308	ENSAPLP00000005446	Hepatocyte nuclear factor 4 alpha.	Uncharacterized protein.	0.567
INS	FOXA2	ENSAPLP00000012854	ENSAPLP00000025594	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Forkhead box A2.	0.548
INS	HNF1A	ENSAPLP00000012854	ENSAPLP00000002032	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Homeobox domain-containing protein.	0.403
INS	HNF4A	ENSAPLP00000012854	ENSAPLP00000024308	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Hepatocyte nuclear factor 4 alpha.	0.587